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Gene Review

Cyp7a1  -  cytochrome P450, family 7, subfamily a,...

Rattus norvegicus

Synonyms: CHAP, CYP7, CYP7S1, CYPVII, Cholesterol 7-alpha-hydroxylase, ...
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Disease relevance of Cyp7a1


Psychiatry related information on Cyp7a1


High impact information on Cyp7a1


Chemical compound and disease context of Cyp7a1


Biological context of Cyp7a1


Anatomical context of Cyp7a1


Associations of Cyp7a1 with chemical compounds


Regulatory relationships of Cyp7a1


Other interactions of Cyp7a1


Analytical, diagnostic and therapeutic context of Cyp7a1


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  14. Studies on the link between HMG-CoA reductase and cholesterol 7 alpha-hydroxylase in lymph-fistula rats: evidence for both transcriptional and post-transcriptional mechanisms for down-regulation of the two enzymes by bile acids. Björkhem, I., Andersson, U., Sudjama-Sugiaman, E., Eggertsen, G., Hylemon, P. J. Lipid Res. (1993) [Pubmed]
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  17. Structural analysis of the gene encoding rat cholesterol alpha-hydroxylase, the key enzyme for bile acid biosynthesis. Nishimoto, M., Gotoh, O., Okuda, K., Noshiro, M. J. Biol. Chem. (1991) [Pubmed]
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  19. Regulation of bile acid synthesis. II. Effect of bile acid feeding on enzymes regulating hepatic cholesterol and bile acid synthesis in the rat. Heuman, D.M., Vlahcevic, Z.R., Bailey, M.L., Hylemon, P.B. Hepatology (1988) [Pubmed]
  20. Feedback regulation of bile-acid synthesis in the rat. Differing effects of taurocholate and tauroursocholate. Shefer, S., Nguyen, L., Salen, G., Batta, A.K., Brooker, D., Zaki, F.G., Rani, I., Tint, G.S. J. Clin. Invest. (1990) [Pubmed]
  21. Bile acid synthesis. VI. Regulation of cholesterol 7 alpha-hydroxylase by taurocholate and mevalonate. Pandak, W.M., Vlahcevic, Z.R., Chiang, J.Y., Heuman, D.M., Hylemon, P.B. J. Lipid Res. (1992) [Pubmed]
  22. Effect of maternal cholestasis and treatment with ursodeoxycholic acid on the expression of genes involved in the secretion of biliary lipids by the neonatal rat liver. Macias, R.I., Jimenez, S., Serrano, M.A., Monte, M.J., Marin, J.J. Life Sci. (2006) [Pubmed]
  23. Oxidative stress and apoptosis in fetal rat liver induced by maternal cholestasis. Protective effect of ursodeoxycholic acid. Perez, M.J., Macias, R.I., Duran, C., Monte, M.J., Gonzalez-Buitrago, J.M., Marin, J.J. J. Hepatol. (2005) [Pubmed]
  24. A novel nonhepatic hydroxycholesterol 7 alpha-hydroxylase that is markedly stimulated by interleukin-1 beta. Characterization in the immature rat ovary. Payne, D.W., Shackleton, C., Toms, H., Ben-Shlomo, I., Kol, S., deMoura, M., Strauss, J.F., Adashi, E.Y. J. Biol. Chem. (1995) [Pubmed]
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  26. Modulation of circadian expression of D-site binding protein by the schedule of parenteral nutrition in rat liver. Ogawa, A., Yano, M., Tsujinaka, T., Morimoto, T., Morita, S., Taniguchi, M., Shiozaki, H., Okamoto, K., Sato, S., Monden, M. Hepatology (1997) [Pubmed]
  27. Regulation of cholesterol 7 alpha-hydroxylase in the liver. Purification of cholesterol 7 alpha-hydroxylase and the immunochemical evidence for the induction of cholesterol 7 alpha-hydroxylase by cholestyramine and circadian rhythm. Chiang, J.Y., Miller, W.F., Lin, G.M. J. Biol. Chem. (1990) [Pubmed]
  28. Studies on the regulation of cholesterol 7 alpha-hydroxylase and HMG-CoA reductase in rat liver: effects of lymphatic drainage and ligation of the lymph duct. Akerlund, J.E., Björkhem, I. J. Lipid Res. (1990) [Pubmed]
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