Gene Review:
CYP7A1 - cytochrome P450, family 7, subfamily A,...
Homo sapiens
Synonyms:
CP7A, CYP7, CYPVII, Cholesterol 7-alpha-hydroxylase, Cholesterol 7-alpha-monooxygenase, ...
Davis,
Miyake,
Hui,
Spann,
Ellis,
Axelson,
Abrahamsson,
Eggertsen,
Thörne,
Nowak,
Ericzon,
Björkhem,
Einarsson,
Norlin,
De Fabiani,
Crestani,
Marrapodi,
Pinelli,
Golfieri,
Galli,
Honda,
Salen,
Matsuzaki,
Batta,
Xu,
Hirayama,
Tint,
Doy,
Shefer,
Goodwin,
Watson,
Kim,
Miao,
Kemper,
Kliewer,
Bertolotti,
Gabbi,
Anzivino,
Mitro,
Godio,
De Fabiani,
Crestani,
Del Puppo,
Ricchi,
Carulli,
Rossi,
Loria,
Carulli,
Pullinger,
Eng,
Salen,
Shefer,
Batta,
Erickson,
Verhagen,
Rivera,
Mulvihill,
Malloy,
Kane,
Rudling,
Angelin,
Ståhle,
Reihnér,
Sahlin,
Olivecrona,
Björkhem,
Einarsson,
Kajinami,
Brousseau,
Ordovas,
Schaefer,
Norlin,
Andersson,
Björkhem,
Wikvall,
Kajinami,
Brousseau,
Ordovas,
Schaefer,
Chiang,
Kimmel,
Weinberger,
Stroup,
- PGC-1alpha activates CYP7A1 and bile acid biosynthesis. Shin, D.J., Campos, J.A., Gil, G., Osborne, T.F. J. Biol. Chem. (2003)
- Regulation of the human cholesterol 7alpha-hydroxylase gene (CYP7A1) by thyroid hormone in transgenic mice. Drover, V.A., Agellon, L.B. Endocrinology (2004)
- Decreased hepatic expression of PPAR-gamma coactivator-1 in cholesterol cholelithiasis. Bertolotti, M., Gabbi, C., Anzivino, C., Mitro, N., Godio, C., De Fabiani, E., Crestani, M., Del Puppo, M., Ricchi, M., Carulli, L., Rossi, A., Loria, P., Carulli, N. Eur. J. Clin. Invest. (2006)
- Cholesterol and hepatic lipoprotein assembly and secretion. Kang, S., Davis, R.A. Biochim. Biophys. Acta (2000)
- Oxysterol 7 alpha-hydroxylase activity by cholesterol 7 alpha-hydroxylase (CYP7A). Norlin, M., Andersson, U., Björkhem, I., Wikvall, K. J. Biol. Chem. (2000)
- Influence of pravastatin, a specific inhibitor of HMG-CoA reductase, on hepatic metabolism of cholesterol. Reihnér, E., Rudling, M., Ståhlberg, D., Berglund, L., Ewerth, S., Björkhem, I., Einarsson, K., Angelin, B. N. Engl. J. Med. (1990)
- A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. Goodwin, B., Jones, S.A., Price, R.R., Watson, M.A., McKee, D.D., Moore, L.B., Galardi, C., Wilson, J.G., Lewis, M.C., Roth, M.E., Maloney, P.R., Willson, T.M., Kliewer, S.A. Mol. Cell (2000)
- Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors. Lu, T.T., Makishima, M., Repa, J.J., Schoonjans, K., Kerr, T.A., Auwerx, J., Mangelsdorf, D.J. Mol. Cell (2000)
- Human cholesterol 7alpha-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype. Pullinger, C.R., Eng, C., Salen, G., Shefer, S., Batta, A.K., Erickson, S.K., Verhagen, A., Rivera, C.R., Mulvihill, S.J., Malloy, M.J., Kane, J.P. J. Clin. Invest. (2002)
- Linkage between cholesterol 7alpha-hydroxylase and high plasma low-density lipoprotein cholesterol concentrations. Wang, J., Freeman, D.J., Grundy, S.M., Levine, D.M., Guerra, R., Cohen, J.C. J. Clin. Invest. (1998)
- One or more labile proteins regulate the stability of chimeric mRNAs containing the 3'-untranslated region of cholesterol-7alpha -hydroxylase mRNA. Baker, D.M., Wang, S.L., Bell, D.J., Drevon, C.A., Davis, R.A. J. Biol. Chem. (2000)
- A distinct thyroid hormone response element mediates repression of the human cholesterol 7alpha-hydroxylase (CYP7A1) gene promoter. Drover, V.A., Wong, N.C., Agellon, L.B. Mol. Endocrinol. (2002)
- Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids. Handschin, C., Gnerre, C., Fraser, D.J., Martinez-Jimenez, C., Jover, R., Meyer, U.A. Arch. Biochem. Biophys. (2005)
- Competitive inhibition of bile acid synthesis by endogenous cholestanol and sitosterol in sitosterolemia with xanthomatosis. Effect on cholesterol 7 alpha-hydroxylase. Shefer, S., Salen, G., Nguyen, L., Batta, A.K., Packin, V., Tint, G.S., Hauser, S. J. Clin. Invest. (1988)
- Bile acids and cytokines inhibit the human cholesterol 7 alpha-hydroxylase gene via the JNK/c-jun pathway in human liver cells. Li, T., Jahan, A., Chiang, J.Y. Hepatology (2006)
- Functional inhibitory cross-talk between constitutive androstane receptor and hepatic nuclear factor-4 in hepatic lipid/glucose metabolism is mediated by competition for binding to the DR1 motif and to the common coactivators, GRIP-1 and PGC-1alpha. Miao, J., Fang, S., Bae, Y., Kemper, J.K. J. Biol. Chem. (2006)
- Differential regulation of rat and human CYP7A1 by the nuclear oxysterol receptor liver X receptor-alpha. Goodwin, B., Watson, M.A., Kim, H., Miao, J., Kemper, J.K., Kliewer, S.A. Mol. Endocrinol. (2003)
- Effect of increasing the expression of cholesterol transporters (StAR, MLN64, and SCP-2) on bile acid synthesis. Ren, S., Hylemon, P., Marques, D., Hall, E., Redford, K., Gil, G., Pandak, W.M. J. Lipid Res. (2004)
- Effects of CYP7A1 overexpression on cholesterol and bile acid homeostasis. Pandak, W.M., Schwarz, C., Hylemon, P.B., Mallonee, D., Valerie, K., Heuman, D.M., Fisher, R.A., Redford, K., Vlahcevic, Z.R. Am. J. Physiol. Gastrointest. Liver Physiol. (2001)
- A Prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4alpha that regulates the cholesterol 7alpha-hydroxylase gene. Song, K.H., Li, T., Chiang, J.Y. J. Biol. Chem. (2006)
- Feedback regulation of bile acid synthesis in primary human hepatocytes: evidence that CDCA is the strongest inhibitor. Ellis, E., Axelson, M., Abrahamsson, A., Eggertsen, G., Thörne, A., Nowak, G., Ericzon, B.G., Björkhem, I., Einarsson, C. Hepatology (2003)
- Differences in the regulation of the classical and the alternative pathway for bile acid synthesis in human liver. No coordinate regulation of CYP7A1 and CYP27A1. Björkhem, I., Araya, Z., Rudling, M., Angelin, B., Einarsson, C., Wikvall, K. J. Biol. Chem. (2002)
- Disrupted coordinate regulation of farnesoid X receptor target genes in a patient with cerebrotendinous xanthomatosis. Honda, A., Salen, G., Matsuzaki, Y., Batta, A.K., Xu, G., Hirayama, T., Tint, G.S., Doy, M., Shefer, S. J. Lipid Res. (2005)
- Identification and characterization of cis-acting elements conferring insulin responsiveness on hamster cholesterol 7alpha-hydroxylase gene promoter. De Fabiani, E., Crestani, M., Marrapodi, M., Pinelli, A., Golfieri, V., Galli, G. Biochem. J. (2000)
- Mechanism of rifampicin and pregnane X receptor inhibition of human cholesterol 7 alpha-hydroxylase gene transcription. Li, T., Chiang, J.Y. Am. J. Physiol. Gastrointest. Liver Physiol. (2005)
- Regulation of cholesterol-7alpha-hydroxylase: BAREly missing a SHP. Davis, R.A., Miyake, J.H., Hui, T.Y., Spann, N.J. J. Lipid Res. (2002)
- Farnesoid X receptor responds to bile acids and represses cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription. Chiang, J.Y., Kimmel, R., Weinberger, C., Stroup, D. J. Biol. Chem. (2000)
- Xol INXS: role of the liver X and the farnesol X receptors. Fayard, E., Schoonjans, K., Auwerx, J. Curr. Opin. Lipidol. (2001)
- Peroxisome proliferator-activated receptor alpha (PPARalpha) and agonist inhibit cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription. Marrapodi, M., Chiang, J.Y. J. Lipid Res. (2000)
- Expression of key enzymes in bile acid biosynthesis during development: CYP7B1-mediated activities show tissue-specific differences. Norlin, M. J. Lipid Res. (2002)
- A promoter polymorphism in cholesterol 7alpha-hydroxylase interacts with apolipoprotein E genotype in the LDL-lowering response to atorvastatin. Kajinami, K., Brousseau, M.E., Ordovas, J.M., Schaefer, E.J. Atherosclerosis (2005)
- Interactions between common genetic polymorphisms in ABCG5/G8 and CYP7A1 on LDL cholesterol-lowering response to atorvastatin. Kajinami, K., Brousseau, M.E., Ordovas, J.M., Schaefer, E.J. Atherosclerosis (2004)
- Regulation of hepatic low-density lipoprotein receptor, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and cholesterol 7alpha-hydroxylase mRNAs in human liver. Rudling, M., Angelin, B., Ståhle, L., Reihnér, E., Sahlin, S., Olivecrona, H., Björkhem, I., Einarsson, C. J. Clin. Endocrinol. Metab. (2002)
- Cholesterol binding to cytochrome P450 7A1, a key enzyme in bile acid biosynthesis. Mast, N., Graham, S.E., Andersson, U., Bjorkhem, I., Hill, C., Peterson, J., Pikuleva, I.A. Biochemistry (2005)
- Correlation of farnesoid X receptor coactivator recruitment and cholesterol 7alpha-hydroxylase gene repression by bile acids. Bramlett, K.S., Yao, S., Burris, T.P. Mol. Genet. Metab. (2000)