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Gene Review

HMGCR  -  3-hydroxy-3-methylglutaryl-CoA reductase

Gallus gallus

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High impact information on RCJMB04_14m24


Biological context of RCJMB04_14m24


Anatomical context of RCJMB04_14m24

  • By Northern blot analysis, chicken HMGR mRNA expression was detected in most tissues examined, however, the highest levels were found in liver, brain and ileum [4].

Associations of RCJMB04_14m24 with chemical compounds


Other interactions of RCJMB04_14m24

  • HMGR and CYP7A1 mRNA levels were significantly increased with maturation (i.e. egg producing), when compared to immature chickens [4].


  1. Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in avian myeloblasts. Mode of action of 25-hydroxycholesterol. Tanaka, R.D., Edwards, P.A., Lan, S.F., Fogelman, A.M. J. Biol. Chem. (1983) [Pubmed]
  2. Select 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors vary in their ability to reduce egg yolk cholesterol levels in laying hens through alteration of hepatic cholesterol biosynthesis and plasma VLDL composition. Elkin, R.G., Yan, Z., Zhong, Y., Donkin, S.S., Buhman, K.K., Story, J.A., Turek, J.J., Porter, R.E., Anderson, M., Homan, R., Newton, R.S. J. Nutr. (1999) [Pubmed]
  3. Dietary alpha-tocopherol attenuates the impact of gamma-tocotrienol on hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in chickens. Qureshi, A.A., Pearce, B.C., Nor, R.M., Gapor, A., Peterson, D.M., Elson, C.E. J. Nutr. (1996) [Pubmed]
  4. Changes in mRNA expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol 7 alpha-hydroxylase in chickens. Sato, K., Ohuchi, A., Sook, S.H., Toyomizu, M., Akiba, Y. Biochim. Biophys. Acta (2003) [Pubmed]
  5. Influence of follicular maturation on 3-hydroxy-methylglutaryl coenzyme A reductase activity in hen granulosa cells. Asem, E.K., Hertelendy, F. J. Reprod. Fertil. (1987) [Pubmed]
  6. Effects of atorvastatin on lipid metabolism in normolipidemic and hereditary hyperlipidemic, non-laying hens. Elkin, R.G., Zhong, Y., Donkin, S.S., Hengstschläger-Ottnad, E., Schneider, W.J. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (2006) [Pubmed]
  7. Relationship between inhibition of mevalonate biosynthesis and reduced fertility in laying hens. Elkin, R.G., Yan, Z. J. Reprod. Fertil. (1999) [Pubmed]
  8. Assessment of egg nutrient compositional changes and residue in eggs, tissues, and excreta following oral administration of atorvastatin to laying hens. Elkin, R.G., Furumoto, E.J., Thomas, C.R. J. Agric. Food Chem. (2003) [Pubmed]
  9. Modulation of regulatory factors involved in cholesterol metabolism in response to feeding of pravastatin- or cholesterol-supplemented diet in chickens. Matsuyama, H., Sato, K., Nakamura, Y., Suzuki, K., Akiba, Y. Biochim. Biophys. Acta (2005) [Pubmed]
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