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Gene Review

CYP2C18  -  cytochrome P450, family 2, subfamily C,...

Gallus gallus

Synonyms: CYP2H2, CYPIIH2
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High impact information on CYP2C18

  • Transient expression analysis established that the promoter activity of the CYP2H2 gene was about ninefold lower than the CYP2H1 gene [1].
  • However, protein binding was observed by in-vitro footprint analysis if either of the HNF-3 sites was mutated in the CYP2H2 promoter [1].

Anatomical context of CYP2C18


  1. A duplicated HNF-3 binding site in the CYP2H2 promoter underlies the weak phenobarbital induction response. Davidson, B.P., Dogra, S.C., May, B.K. Int. J. Biochem. Cell Biol. (2001) [Pubmed]
  2. Inhibition of protein synthesis increases the transcription of the phenobarbital-inducible CYP2H1 and CYP2H2 genes in chick embryo hepatocytes. Hamilton, J.W., Bement, W.J., Sinclair, P.R., Sinclair, J.F., Alcedo, J.A., Wetterhahn, K.E. Arch. Biochem. Biophys. (1992) [Pubmed]
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