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Gene Review

Cyp2c23  -  cytochrome P450, family 2, subfamily c,...

Rattus norvegicus

Synonyms: Arachidonic acid epoxygenase, CYPIIC23, Cyp2c-23, Cytochrome P450 2C23
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Disease relevance of Cyp2c23


High impact information on Cyp2c23


Chemical compound and disease context of Cyp2c23


Biological context of Cyp2c23


Anatomical context of Cyp2c23


Associations of Cyp2c23 with chemical compounds


Regulatory relationships of Cyp2c23


Other interactions of Cyp2c23


Analytical, diagnostic and therapeutic context of Cyp2c23


  1. Tumor necrosis factor alpha blockade increases renal Cyp2c23 expression and slows the progression of renal damage in salt-sensitive hypertension. Elmarakby, A.A., Quigley, J.E., Pollock, D.M., Imig, J.D. Hypertension (2006) [Pubmed]
  2. The kidney cytochrome P-450 2C23 arachidonic acid epoxygenase is upregulated during dietary salt loading. Holla, V.R., Makita, K., Zaphiropoulos, P.G., Capdevila, J.H. J. Clin. Invest. (1999) [Pubmed]
  3. Molecular cloning, expression, and enzymatic characterization of the rat kidney cytochrome P-450 arachidonic acid epoxygenase. Karara, A., Makita, K., Jacobson, H.R., Falck, J.R., Guengerich, F.P., DuBois, R.N., Capdevila, J.H. J. Biol. Chem. (1993) [Pubmed]
  4. Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase. Capdevila, J.H., Karara, A., Waxman, D.J., Martin, M.V., Falck, J.R., Guenguerich, F.P. J. Biol. Chem. (1990) [Pubmed]
  5. Role of P-450 arachidonic acid epoxygenase in the response of cerebral blood flow to glutamate in rats. Alkayed, N.J., Birks, E.K., Narayanan, J., Petrie, K.A., Kohler-Cabot, A.E., Harder, D.R. Stroke (1997) [Pubmed]
  6. Molecular characterization of an arachidonic acid epoxygenase in rat brain astrocytes. Alkayed, N.J., Narayanan, J., Gebremedhin, D., Medhora, M., Roman, R.J., Harder, D.R. Stroke (1996) [Pubmed]
  7. Epoxygenase metabolites of arachidonic acid affect electrophysiologic properties of rat tracheal epithelial cells1. Pascual, J.M., McKenzie, A., Yankaskas, J.R., Falck, J.R., Zeldin, D.C. J. Pharmacol. Exp. Ther. (1998) [Pubmed]
  8. Inhibitors of cytochrome P-450-dependent arachidonic acid metabolism. Capdevila, J., Gil, L., Orellana, M., Marnett, L.J., Mason, J.I., Yadagiri, P., Falck, J.R. Arch. Biochem. Biophys. (1988) [Pubmed]
  9. Epoxygenation of arachidonic acid by rat anterior pituitary microsomal fractions. Capdevila, J., Snijder, G.D., Falck, J.R. FEBS Lett. (1984) [Pubmed]
  10. Epoxyeicosatrienoic acids stimulate glucagon and insulin release from isolated rat pancreatic islets. Falck, J.R., Manna, S., Moltz, J., Chacos, N., Capdevila, J. Biochem. Biophys. Res. Commun. (1983) [Pubmed]
  11. NADPH-dependent microsomal metabolism of 14,15-epoxyeicosatrienoic acid to diepoxides and epoxyalcohols. Capdevila, J.H., Mosset, P., Yadagiri, P., Lumin, S., Falck, J.R. Arch. Biochem. Biophys. (1988) [Pubmed]
  12. Effect of epoxyeicosatrienoic acids on growth hormone release from somatotrophs. Snyder, G.D., Yadagiri, P., Falck, J.R. Am. J. Physiol. (1989) [Pubmed]
  13. Neuroprotection and P450 2C11 upregulation after experimental transient ischemic attack. Alkayed, N.J., Goyagi, T., Joh, H.D., Klaus, J., Harder, D.R., Traystman, R.J., Hurn, P.D. Stroke (2002) [Pubmed]
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