Gene Review:
CYP2H1 - cytochrome P450 2H1
Gallus gallus
- CXR, a chicken xenobiotic-sensing orphan nuclear receptor, is related to both mammalian pregnane X receptor (PXR) and constitutive androstane receptor (CAR). Handschin, C., Podvinec, M., Meyer, U.A. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Liver-enriched transcription factors, HNF-1, HNF-3, and C/EBP, are major contributors to the strong activity of the chicken CYP2H1 promoter in chick embryo hepatocytes. Dogra, S.C., May, B.K. DNA Cell Biol. (1997)
- A conserved nuclear receptor consensus sequence (DR-4) mediates transcriptional activation of the chicken CYP2H1 gene by phenobarbital in a hepatoma cell line. Handschin, C., Meyer, U.A. J. Biol. Chem. (2000)
- Transcriptional regulation of the chicken CYP2H1 gene. Localization of a phenobarbital-responsive enhancer domain. Hahn, C.N., Hansen, A.J., May, B.K. J. Biol. Chem. (1991)
- Conservation of signaling pathways of xenobiotic-sensing orphan nuclear receptors, chicken xenobiotic receptor, constitutive androstane receptor, and pregnane X receptor, from birds to humans. Handschin, C., Podvinec, M., Stöckli, J., Hoffmann, K., Meyer, U.A. Mol. Endocrinol. (2001)
- A Link between cholesterol levels and phenobarbital induction of cytochromes P450. Ourlin, J.C., Handschin, C., Kaufmann, M., Meyer, U.A. Biochem. Biophys. Res. Commun. (2002)
- Multiple enhancer units mediate drug induction of CYP2H1 by xenobiotic-sensing orphan nuclear receptor chicken xenobiotic receptor. Handschin, C., Podvinec, M., Looser, R., Amherd, R., Meyer, U.A. Mol. Pharmacol. (2001)
- Analysis of a phenobarbital-responsive enhancer sequence located in the 5' flanking region of the chicken CYP2H1 gene: identification and characterization of functional protein-binding sites. Dogra, S.C., Davidson, B.P., May, B.K. Mol. Pharmacol. (1999)
- Phenobarbital-induced activation of CYP2H1 and 5-aminolevulinate synthase genes in chick embryo hepatocytes is blocked by an inhibitor of protein phosphorylation. Dogra, S.C., May, B.K. Arch. Biochem. Biophys. (1996)
- The antiglucocorticoid RU486 inhibits phenobarbital induction of the chicken CYP2H1 gene in primary hepatocytes. Davidson, B.P., Dogra, S.C., May, B.K. Mol. Pharmacol. (2001)
- Inhibition of protein synthesis increases the transcription of the phenobarbital-inducible CYP2H1 and CYP2H2 genes in chick embryo hepatocytes. Hamilton, J.W., Bement, W.J., Sinclair, P.R., Sinclair, J.F., Alcedo, J.A., Wetterhahn, K.E. Arch. Biochem. Biophys. (1992)
- Evidence that the coactivator CBP/p300 is important for phenobarbital-induced but not basal expression of the CYP2H1 gene. Dogra, S.C., Tremethick, D., May, B.K. Mol. Pharmacol. (2003)
- Preferential effects of the chemotherapeutic DNA crosslinking agent mitomycin C on inducible gene expression in vivo. Caron, R.M., Hamilton, J.W. Environ. Mol. Mutagen. (1995)
- A duplicated HNF-3 binding site in the CYP2H2 promoter underlies the weak phenobarbital induction response. Davidson, B.P., Dogra, S.C., May, B.K. Int. J. Biochem. Cell Biol. (2001)
- Comparative evaluation of phenobarbital-induced CYP3A and CYP2H1 gene expression by quantitative RT-PCR in Bantam, Bantamized White Leghorn and White Leghorn chicks. Goriya, H.V., Kalia, A., Bhavsar, S.K., Joshi, C.G., Rank, D.N., Thaker, A.M. J. Vet. Sci. (2005)
- Mechanism of the synergistic induction of CYP2H by isopentanol plus ethanol: comparison to glutethimide and relation to induction of 5-aminolevulinate synthase. Louis, C.A., Wood, S.G., Walton, H.S., Sinclair, P.R., Sinclair, J.F. Arch. Biochem. Biophys. (1998)