Gene Review:
FOXM1 - forkhead box M1
Homo sapiens
Synonyms:
FKHL16, FOXM1B, Forkhead box protein M1, Forkhead-related protein FKHL16, HFH-11, ...
Wierstra,
Alves,
Korver,
Roose,
Heinen,
Weghuis,
de Bruijn,
van Kessel,
Clevers,
D'Antonio,
Capello,
Manley,
Naughton,
Sutton,
Spek,
Bertina,
Reitsma,
Lang,
Fukuda,
Zhang,
Mikoshiba,
Wollheim,
De Fabiani,
Crestani,
Marrapodi,
Pinelli,
Golfieri,
Galli,
Katoh,
Katoh,
Douard,
Moutereau,
Pernet,
Chimingqi,
Allory,
Manivet,
Conti,
Vaubourdolle,
Cugnenc,
Loric,
Wierstra,
Alves,
Wierup,
Yang,
McEvilly,
Mulder,
Sundler,
Gusarova,
Wang,
Major,
Kalinichenko,
Ackerson,
Petrovic,
Costa,
Millar,
Johansen,
Berntorp,
Minford,
Bolton-Maggs,
Wensley,
Kakkar,
Schulman,
Torres,
Bosch,
Cooper,
- FOXM1 is a downstream target of Gli1 in basal cell carcinomas. Teh, M.T., Wong, S.T., Neill, G.W., Ghali, L.R., Philpott, M.P., Quinn, A.G. Cancer Res. (2002)
- Sonic Hedgehog-dependent proliferation in a series of patients with colorectal cancer. Douard, R., Moutereau, S., Pernet, P., Chimingqi, M., Allory, Y., Manivet, P., Conti, M., Vaubourdolle, M., Cugnenc, P.H., Loric, S. Surgery (2006)
- Human FOX gene family (Review). Katoh, M., Katoh, M. Int. J. Oncol. (2004)
- Increased levels of the FoxM1 transcription factor accelerate development and progression of prostate carcinomas in both TRAMP and LADY transgenic mice. Kalin, T.V., Wang, I.C., Ackerson, T.J., Major, M.L., Detrisac, C.J., Kalinichenko, V.V., Lyubimov, A., Costa, R.H. Cancer Res. (2006)
- A cell-penetrating ARF peptide inhibitor of FoxM1 in mouse hepatocellular carcinoma treatment. Gusarova, G.A., Wang, I.C., Major, M.L., Kalinichenko, V.V., Ackerson, T., Petrovic, V., Costa, R.H. J. Clin. Invest. (2007)
- Stable expression of manganese superoxide dismutase (MnSOD) in insulinoma cells prevents IL-1beta- induced cytotoxicity and reduces nitric oxide production. Hohmeier, H.E., Thigpen, A., Tran, V.V., Davis, R., Newgard, C.B. J. Clin. Invest. (1998)
- The first C2 domain of synaptotagmin is required for exocytosis of insulin from pancreatic beta-cells: action of synaptotagmin at low micromolar calcium. Lang, J., Fukuda, M., Zhang, H., Mikoshiba, K., Wollheim, C.B. EMBO J. (1997)
- Solution structure of the LexA repressor DNA binding domain determined by 1H NMR spectroscopy. Fogh, R.H., Ottleben, G., Rüterjans, H., Schnarr, M., Boelens, R., Kaptein, R. EMBO J. (1994)
- The winged helix transcription factor HFH-4 is expressed during choroid plexus epithelial development in the mouse embryo. Lim, L., Zhou, H., Costa, R.H. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Induction by glucose of genes coding for glycolytic enzymes in a pancreatic beta-cell line (INS-1). Roche, E., Assimacopoulos-Jeannet, F., Witters, L.A., Perruchoud, B., Yaney, G., Corkey, B., Asfari, M., Prentki, M. J. Biol. Chem. (1997)
- Dominant-negative suppression of HNF-1 alpha results in mitochondrial dysfunction, INS-1 cell apoptosis, and increased sensitivity to ceramide-, but not to high glucose-induced cell death. Wobser, H., Düssmann, H., Kögel, D., Wang, H., Reimertz, C., Wollheim, C.B., Byrne, M.M., Prehn, J.H. J. Biol. Chem. (2002)
- Forced expression of Genesis, a winged helix transcriptional repressor isolated from embryonic stem cells, blocks granulocytic differentiation of 32D myeloid cells. Xu, D., Yoder, M., Sutton, J., Hromas, R. Leukemia (1998)
- A titanium-encased alumina ceramic bearing for total hip arthroplasty: 3- to 5-year results. D'Antonio, J.A., Capello, W.N., Manley, M.T., Naughton, M., Sutton, K. Clin. Orthop. Relat. Res. (2005)
- Troglitazone ameliorates lipotoxicity in the beta cell line INS-1 expressing PPAR gamma. Kawai, T., Hirose, H., Seto, Y., Fujita, H., Fujita, H., Ukeda, K., Saruta, T. Diabetes Res. Clin. Pract. (2002)
- Regulation of the transcription factor FOXM1c by Cyclin E/CDK2. Lüscher-Firzlaff, J.M., Lilischkis, R., Lüscher, B. FEBS Lett. (2006)
- Despite its strong transactivation domain, transcription factor FOXM1c is kept almost inactive by two different inhibitory domains. Wierstra, I., Alves, J. Biol. Chem. (2006)
- Transcription factor FOXM1c is repressed by RB and activated by cyclin D1/Cdk4. Wierstra, I., Alves, J. Biol. Chem. (2006)
- Cloning of cDNAs for M-phase phosphoproteins recognized by the MPM2 monoclonal antibody and determination of the phosphorylated epitope. Westendorf, J.M., Rao, P.N., Gerace, L. Proc. Natl. Acad. Sci. U.S.A. (1994)
- The effect of suppressor of cytokine signaling 3 on GH signaling in beta-cells. Rønn, S.G., Hansen, J.A., Lindberg, K., Karlsen, A.E., Billestrup, N. Mol. Endocrinol. (2002)
- Interaction between STAT-3 and HNF-3 leads to the activation of liver-specific hepatitis B virus enhancer 1 function. Waris, G., Siddiqui, A. J. Virol. (2002)
- The human TRIDENT/HFH-11/FKHL16 gene: structure, localization, and promoter characterization. Korver, W., Roose, J., Heinen, K., Weghuis, D.O., de Bruijn, D., van Kessel, A.G., Clevers, H. Genomics (1997)
- FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site. Raum, J.C., Gerrish, K., Artner, I., Henderson, E., Guo, M., Sussel, L., Schisler, J.C., Newgard, C.B., Stein, R. Mol. Cell. Biol. (2006)
- The Schizosaccharomyces pombe mei4+ gene encodes a meiosis-specific transcription factor containing a forkhead DNA-binding domain. Horie, S., Watanabe, Y., Tanaka, K., Nishiwaki, S., Fujioka, H., Abe, H., Yamamoto, M., Shimoda, C. Mol. Cell. Biol. (1998)
- Essentiality of intron control in the induction of c-fos by glucose and glucoincretin peptides in INS-1 beta-cells. Susini, S., Van Haasteren, G., Li, S., Prentki, M., Schlegel, W. FASEB J. (2000)
- The molecular physiology of hepatic nuclear factor 3 in the regulation of gluconeogenesis. Wang, J.C., Stafford, J.M., Scott, D.K., Sutherland, C., Granner, D.K. J. Biol. Chem. (2000)
- Identification and characterization of cis-acting elements conferring insulin responsiveness on hamster cholesterol 7alpha-hydroxylase gene promoter. De Fabiani, E., Crestani, M., Marrapodi, M., Pinelli, A., Golfieri, V., Galli, G. Biochem. J. (2000)
- Molecular genetic analysis of severe protein C deficiency. Millar, D.S., Johansen, B., Berntorp, E., Minford, A., Bolton-Maggs, P., Wensley, R., Kakkar, V., Schulman, S., Torres, A., Bosch, N., Cooper, D.N. Hum. Genet. (2000)
- GH signalling in pancreatic beta-cells. Sekine, N., Wollheim, C.B., Fujita, T. Endocr. J. (1998)
- Unique distance- and DNA-turn-dependent interactions in the human protein C gene promoter confer submaximal transcriptional activity. Spek, C.A., Bertina, R.M., Reitsma, P.H. Biochem. J. (1999)
- Characterization of the human lipoprotein lipase (LPL) promoter: evidence of two cis-regulatory regions, LP-alpha and LP-beta, of importance for the differentiation-linked induction of the LPL gene during adipogenesis. Enerbäck, S., Ohlsson, B.G., Samuelsson, L., Bjursell, G. Mol. Cell. Biol. (1992)
- Transcriptional regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte nuclear factor-3 gamma. Rodríguez-Antona, C., Bort, R., Jover, R., Tindberg, N., Ingelman-Sundberg, M., Gómez-Lechón, M.J., Castell, J.V. Mol. Pharmacol. (2003)
- The Forkhead box M1 protein regulates the transcription of the estrogen receptor alpha in breast cancer cells. Madureira, P.A., Varshochi, R., Constantinidou, D., Francis, R.E., Coombes, R.C., Yao, K.M., Lam, E.W. J. Biol. Chem. (2006)
- Expression of the transcription factor STAT-1 alpha in insulinoma cells protects against cytotoxic effects of multiple cytokines. Chen, G., Hohmeier, H.E., Newgard, C.B. J. Biol. Chem. (2001)
- TRPM4 controls insulin secretion in pancreatic beta-cells. Cheng, H., Beck, A., Launay, P., Gross, S.A., Stokes, A.J., Kinet, J.P., Fleig, A., Penner, R. Cell Calcium (2007)
- Ghrelin is expressed in a novel endocrine cell type in developing rat islets and inhibits insulin secretion from INS-1 (832/13) cells. Wierup, N., Yang, S., McEvilly, R.J., Mulder, H., Sundler, F. J. Histochem. Cytochem. (2004)
- Identification and characterization of rat Desert hedgehog and Indian hedgehog genes in silico. Katoh, Y., Katoh, M. Int. J. Oncol. (2005)
- Hedgehog signaling pathway and gastric cancer. Katoh, Y., Katoh, M. Cancer Biol. Ther. (2005)
- A roller coaster ride with the mitotic cyclins. Fung, T.K., Poon, R.Y. Semin. Cell Dev. Biol. (2005)
- Cloning of a cellular factor, interleukin binding factor, that binds to NFAT-like motifs in the human immunodeficiency virus long terminal repeat. Li, C., Lai, C.F., Sigman, D.S., Gaynor, R.B. Proc. Natl. Acad. Sci. U.S.A. (1991)
- Hepatocyte nuclear factor 3 activates transcription of thyroid transcription factor 1 in respiratory epithelial cells. Ikeda, K., Shaw-White, J.R., Wert, S.E., Whitsett, J.A. Mol. Cell. Biol. (1996)
- Discrete and complementary mechanisms of protection of beta-cells against cytokine-induced and oxidative damage achieved by bcl-2 overexpression and a cytokine selection strategy. Tran, V.V., Chen, G., Newgard, C.B., Hohmeier, H.E. Diabetes (2003)
- Hepatic nuclear factor 3 and nuclear factor 1 regulate 5-aminolevulinate synthase gene expression and are involved in insulin repression. Scassa, M.E., Guberman, A.S., Ceruti, J.M., Cánepa, E.T. J. Biol. Chem. (2004)