The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

emb  -  embargoed

Drosophila melanogaster

Synonyms: CG13387, CRM1, Chromosome region maintenance 1 protein, Crm1, DCRM1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on emb


Biological context of emb

  • Nuclear import of an nuclear localization signal-enhanced green fluorescent protein (NLS-EGFP) reporter is not affected in DNup88 (members only; mbo) mutants, whereas the level of CRM1-dependent EGFP-nuclear export signal (EGFP-NES) export is increased [3].
  • Through mutagenesis screens we have recovered a series of recessive lethal emb mutations [4].

Anatomical context of emb


Associations of emb with chemical compounds


Physical interactions of emb


Other interactions of emb


  1. Antagonistic regulation of Yan nuclear export by Mae and Crm1 may increase the stringency of the Ras response. Song, H., Nie, M., Qiao, F., Bowie, J.U., Courey, A.J. Genes Dev. (2005) [Pubmed]
  2. Control of the nuclear localization of Extradenticle by competing nuclear import and export signals. Abu-Shaar, M., Ryoo, H.D., Mann, R.S. Genes Dev. (1999) [Pubmed]
  3. The Drosophila nucleoporin DNup88 localizes DNup214 and CRM1 on the nuclear envelope and attenuates NES-mediated nuclear export. Roth, P., Xylourgidis, N., Sabri, N., Uv, A., Fornerod, M., Samakovlis, C. J. Cell Biol. (2003) [Pubmed]
  4. The Drosophila embargoed gene is required for larval progression and encodes the functional homolog of schizosaccharomyces Crm1. Collier, S., Chan, H.Y., Toda, T., McKimmie, C., Johnson, G., Adler, P.N., O'Kane, C., Ashburner, M. Genetics (2000) [Pubmed]
  5. Structure and expression of novel protein-tyrosine kinases, Emb and Emt, in hematopoietic cells. Yamada, N., Kawakami, Y., Kimura, H., Fukamachi, H., Baier, G., Altman, A., Kato, T., Inagaki, Y., Kawakami, T. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  6. A leptomycin B-sensitive homologue of human CRM1 promotes nuclear export of nuclear export sequence-containing proteins in Drosophila cells. Fasken, M.B., Saunders, R., Rosenberg, M., Brighty, D.W. J. Biol. Chem. (2000) [Pubmed]
  7. The nucleoporin Nup214 sequesters CRM1 at the nuclear rim and modulates NF{kappa}B activation in Drosophila. Xylourgidis, N., Roth, P., Sabri, N., Tsarouhas, V., Samakovlis, C. J. Cell. Sci. (2006) [Pubmed]
  8. CRM1-mediated nuclear export and regulated activity of the Receptor Tyrosine Kinase antagonist YAN require specific interactions with MAE. Tootle, T.L., Lee, P.S., Rebay, I. Development (2003) [Pubmed]
WikiGenes - Universities