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Gene Review

emb  -  embargoed

Drosophila melanogaster

Synonyms: CG13387, CRM1, Chromosome region maintenance 1 protein, Crm1, DCRM1, ...
 
 
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High impact information on emb

 

Biological context of emb

  • Nuclear import of an nuclear localization signal-enhanced green fluorescent protein (NLS-EGFP) reporter is not affected in DNup88 (members only; mbo) mutants, whereas the level of CRM1-dependent EGFP-nuclear export signal (EGFP-NES) export is increased [3].
  • Through mutagenesis screens we have recovered a series of recessive lethal emb mutations [4].
 

Anatomical context of emb

 

Associations of emb with chemical compounds

 

Physical interactions of emb

 

Other interactions of emb

References

  1. Antagonistic regulation of Yan nuclear export by Mae and Crm1 may increase the stringency of the Ras response. Song, H., Nie, M., Qiao, F., Bowie, J.U., Courey, A.J. Genes Dev. (2005) [Pubmed]
  2. Control of the nuclear localization of Extradenticle by competing nuclear import and export signals. Abu-Shaar, M., Ryoo, H.D., Mann, R.S. Genes Dev. (1999) [Pubmed]
  3. The Drosophila nucleoporin DNup88 localizes DNup214 and CRM1 on the nuclear envelope and attenuates NES-mediated nuclear export. Roth, P., Xylourgidis, N., Sabri, N., Uv, A., Fornerod, M., Samakovlis, C. J. Cell Biol. (2003) [Pubmed]
  4. The Drosophila embargoed gene is required for larval progression and encodes the functional homolog of schizosaccharomyces Crm1. Collier, S., Chan, H.Y., Toda, T., McKimmie, C., Johnson, G., Adler, P.N., O'Kane, C., Ashburner, M. Genetics (2000) [Pubmed]
  5. Structure and expression of novel protein-tyrosine kinases, Emb and Emt, in hematopoietic cells. Yamada, N., Kawakami, Y., Kimura, H., Fukamachi, H., Baier, G., Altman, A., Kato, T., Inagaki, Y., Kawakami, T. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  6. A leptomycin B-sensitive homologue of human CRM1 promotes nuclear export of nuclear export sequence-containing proteins in Drosophila cells. Fasken, M.B., Saunders, R., Rosenberg, M., Brighty, D.W. J. Biol. Chem. (2000) [Pubmed]
  7. The nucleoporin Nup214 sequesters CRM1 at the nuclear rim and modulates NF{kappa}B activation in Drosophila. Xylourgidis, N., Roth, P., Sabri, N., Tsarouhas, V., Samakovlis, C. J. Cell. Sci. (2006) [Pubmed]
  8. CRM1-mediated nuclear export and regulated activity of the Receptor Tyrosine Kinase antagonist YAN require specific interactions with MAE. Tootle, T.L., Lee, P.S., Rebay, I. Development (2003) [Pubmed]
 
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