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Gene Review

GlyS  -  Glycogen synthase

Drosophila melanogaster

Synonyms: CG6904, CG6940, Dmel\CG6904, GS, anon-WO0118547.108
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High impact information on CG6904

  • We found that Shaggy (Sgg), the Drosophila homolog of the mammalian glycogen synthase kinases 3 alpha and beta, two serine-threonine kinases, was concentrated at this synapse [1].
  • The c-Jun oncoprotein may have the potential to transform cells but this does not excuse it from similar mechanisms of control to glycogen synthase [2].
  • Glycogen synthase is a critical enzyme regulating glucose storage [2].
  • While at first sight a role in transcriptional regulation appears unlikely for a protein first identified as acting on glycogen synthase, it is even more surprising that the same protein should be functionally interchangeable with a fruit fly homeotic gene [2].


  1. Shaggy, the homolog of glycogen synthase kinase 3, controls neuromuscular junction growth in Drosophila. Franco, B., Bogdanik, L., Bobinnec, Y., Debec, A., Bockaert, J., Parmentier, M.L., Grau, Y. J. Neurosci. (2004) [Pubmed]
  2. Glycogen synthase kinase-3: functions in oncogenesis and development. Plyte, S.E., Hughes, K., Nikolakaki, E., Pulverer, B.J., Woodgett, J.R. Biochim. Biophys. Acta (1992) [Pubmed]
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