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Gene Review

GlyS  -  Glycogen synthase

Drosophila melanogaster

Synonyms: CG6904, CG6940, Dmel\CG6904, GS, anon-WO0118547.108
 
 
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High impact information on CG6904

  • We found that Shaggy (Sgg), the Drosophila homolog of the mammalian glycogen synthase kinases 3 alpha and beta, two serine-threonine kinases, was concentrated at this synapse [1].
  • The c-Jun oncoprotein may have the potential to transform cells but this does not excuse it from similar mechanisms of control to glycogen synthase [2].
  • Glycogen synthase is a critical enzyme regulating glucose storage [2].
  • While at first sight a role in transcriptional regulation appears unlikely for a protein first identified as acting on glycogen synthase, it is even more surprising that the same protein should be functionally interchangeable with a fruit fly homeotic gene [2].

References

  1. Shaggy, the homolog of glycogen synthase kinase 3, controls neuromuscular junction growth in Drosophila. Franco, B., Bogdanik, L., Bobinnec, Y., Debec, A., Bockaert, J., Parmentier, M.L., Grau, Y. J. Neurosci. (2004) [Pubmed]
  2. Glycogen synthase kinase-3: functions in oncogenesis and development. Plyte, S.E., Hughes, K., Nikolakaki, E., Pulverer, B.J., Woodgett, J.R. Biochim. Biophys. Acta (1992) [Pubmed]
 
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