Gene Review:
UBE3A - ubiquitin protein ligase E3A
Gallus gallus
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Disease relevance of UBE3A
- UBE3A, the gene associated with Angelman syndrome, is part of a cluster of genes in the human chromosome 15q11-q13/mouse chromosome 7C region, that is subject to genomic imprinting [1].
High impact information on UBE3A
- Biallelic expression of UBE3A is observed in embryonic chicken brain and limb, indicating that UBE3A is not subject to genomic imprinting in chicken [1].
- We have assembled the predicted mRNA consensus sequence for the chicken UBE3A gene using published ESTs [1].
References
- Genomic organization and allelic expression of UBE3A in chicken. Colosi, D.C., Martin, D., Mor??, K., Lalande, M. Gene (2006) [Pubmed]
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