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Gene Review: 

MED17  -  Mediator complex subunit 17

Drosophila melanogaster

Synonyms: CG7957, Dmel\CG7957, Med17, Mediator of RNA polymerase II transcription subunit 17, TRAP80, ...
 
 
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High impact information on MED17

  • Synergistic genetic interactions support shared developmental cell and segment identity functions of dTRAP240 and dTRAP80, potentially within a common complex [1].
  • Clonal analysis indicates a general role for dTRAP80 necessary for cell viability [1].
  • Moreover, up-regulation of Drosophila p70/S6 kinase activity in DILP neurons led to attenuated hunger response by fasted larvae, whereas its down-regulation triggered fed larvae to display motivated foraging and feeding [2].
  • Signal-induced transcriptional activation by Dif requires the dTRAP80 mediator module [3].
  • The distinct phenotypes associated with certain mutations in some of the Mediator genes and the specific in vitro interactions of Mediator gene products with transcriptional activator proteins suggest the presence of activator-specific binding subunits within the Mediator complex [3].
 

Associations of MED17 with chemical compounds

  • The subunits shared among the three Mediator complexes (C1, C2, and C3) appear to form a stable modular structure that serves as a binding surface for transcriptional activator proteins [4].

References

  1. Drosophila homologs of transcriptional mediator complex subunits are required for adult cell and segment identity specification. Boube, M., Faucher, C., Joulia, L., Cribbs, D.L., Bourbon, H.M. Genes Dev. (2000) [Pubmed]
  2. Regulation of hunger-driven behaviors by neural ribosomal S6 kinase in Drosophila. Wu, Q., Zhang, Y., Xu, J., Shen, P. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. Signal-induced transcriptional activation by Dif requires the dTRAP80 mediator module. Park, J.M., Kim, J.M., Kim, L.K., Kim, S.N., Kim-Ha, J., Kim, J.H., Kim, Y.J. Mol. Cell. Biol. (2003) [Pubmed]
  4. Novel Mediator proteins of the small Mediator complex in Drosophila SL2 cells. Gu, J.Y., Park, J.M., Song, E.J., Mizuguchi, G., Yoon, J.H., Kim-Ha, J., Lee, K.J., Kim, Y.J. J. Biol. Chem. (2002) [Pubmed]
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