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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Mekk1  -  CG7717 gene product from transcript CG7717-RB

Drosophila melanogaster

Synonyms: CG7717, D-MEKK1, D-Mekk1, DmMEKK1, Dmel\CG7717, ...
 
 
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High impact information on Mekk1

  • The MAPKKK Mekk1 regulates the expression of Turandot stress genes in response to septic injury in Drosophila [1].
  • Interestingly, Mekk1 flies are resistant to microbial infection but susceptible to paraquat, an inducer of oxidative stress [1].
  • Recent studies have described the distinct phenotypic consequences of mutations in three of the genes, Slpr (dMLK), Tak1, and Mekk1 [2].
 

Other interactions of Mekk1

  • Our analysis indicates that Tot genes show a complex regulation pattern including signals from both the JAK-STAT and Imd pathways and Mekk1 [1].
 

Analytical, diagnostic and therapeutic context of Mekk1

References

  1. The MAPKKK Mekk1 regulates the expression of Turandot stress genes in response to septic injury in Drosophila. Brun, S., Vidal, S., Spellman, P., Takahashi, K., Tricoire, H., Lemaitre, B. Genes Cells (2006) [Pubmed]
  2. Dissecting JNK signaling, one KKKinase at a time. Stronach, B. Dev. Dyn. (2005) [Pubmed]
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