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Gene Review

Map3k4  -  mitogen-activated protein kinase kinase...

Mus musculus

Synonyms: D17Rp17, D17Rp17e, MAPK/ERK kinase kinase 4, MAPKKK4, MEK kinase 4, ...
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High impact information on Map3k4

  • The forming acini expressed BRCA1, GADD45beta, MEKK4, and the JNK activating complex GADD 45beta-MEKK4 in a glucocorticoid-dependent fashion [1].
  • Dominant negative forms of MEKK1 and MEKK4 were expressed stably in the clones harboring Q226L Galpha13 [2].
  • Expression of dominant negative versions of either MEKK1 or MEKK4 effectively blocks both the activation of Jun N-terminal kinase as well as the formation of primitive endoderm [2].
  • Neither t-specific nor wild-type D17Rp17 alleles are present in chromosomes carrying either the T Orleans (TtOrl) or the T hairpin tail (Thp) deletions [3].
  • A study of several t haplotypes resulted in the identification of t-specific alleles of D17Rp17 that map to the proximal half of the t complex [3].

Anatomical context of Map3k4


Other interactions of Map3k4

  • The map distances have been determined for the DNA loci in the T-H-2 interval and the Hst-1 gene was mapped in close vicinity to the D17Rp17 locus [5].
  • We describe here a 1.2-Mb yeast artificial chromosome (YAC) contig within the region of mouse chromosome 17 between Brachyury (T) and D17Rp17e, and spanning the quaking (qk) region [6].
  • Detailed physical and genetic mapping in the region of plasminogen, D17Rp17e, and quaking [7].
  • The genetic distance to D17Rp17e from D17Leh511 is also 0.15 cM; the physical distance of less than 360 kb (minimum 200 kb) is consistent with an approximation of 2 Mbp per cM [7].

Analytical, diagnostic and therapeutic context of Map3k4

  • Both allowed visualization of the 140 kDa c-kit protein by Western blot analysis, but MTK1 detected only positive band with non-reducing conditions for sodium dodecyl sulfate-polyacrylamide gel electrophoresis [4].


  1. Organization of mammary epithelial cells into 3D acinar structures requires glucocorticoid and JNK signaling. Murtagh, J., McArdle, E., Gilligan, E., Thornton, L., Furlong, F., Martin, F. J. Cell Biol. (2004) [Pubmed]
  2. Expression of Galpha 13 (Q226L) induces P19 stem cells to primitive endoderm via MEKK1, 2, or 4. Wang, H.Y., Kanungo, J., Malbon, C.C. J. Biol. Chem. (2002) [Pubmed]
  3. Genetic analysis of a mouse t complex locus that is homologous to a kidney cDNA clone. Mann, E.A., Silver, L.M., Elliott, R.W. Genetics (1986) [Pubmed]
  4. Isolation and characterization of two monoclonal antibodies that recognize different epitopes of the human c-kit receptor. Morita, S., Tsuchiya, S., Fujie, H., Itano, M., Ohashi, Y., Minegishi, M., Konno, T. Tohoku J. Exp. Med. (1996) [Pubmed]
  5. Genetic mapping of the t-complex region on mouse chromosome 17 including the Hybrid sterility-1 gene. Forejt, J., Vincek, V., Klein, J., Lehrach, H., Loudová-Micková, M. Mamm. Genome (1991) [Pubmed]
  6. A 1.2-Mb YAC contig spans the quaking region. Cox, R.D., Shedlovsky, A., Hamvas, R., Goldsworthy, M., Whittington, J., Connelly, C.S., Dove, W.F., Lehrach, H. Genomics (1994) [Pubmed]
  7. Detailed physical and genetic mapping in the region of plasminogen, D17Rp17e, and quaking. Cox, R.D., Whittington, J., Shedlovsky, A., Connelly, C.S., Dove, W.F., Goldsworthy, M., Larin, Z., Lehrach, H. Mamm. Genome (1993) [Pubmed]
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