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Gene Review

CTBP1  -  C-terminal binding protein 1

Gallus gallus

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Disease relevance of RCJMB04_22g9


High impact information on RCJMB04_22g9

  • We also demonstrate that the nononcogenic MDV generated by mutagenesis of the CtBP-interaction domain of MEQ has the potential to be an improved vaccine against virulent MDV infection [1].
  • MEQ sequence shows a Pro-Leu-Asp-Leu-Ser (PLDLS) motif known to bind C-terminal-binding protein (CtBP), a highly conserved cellular transcriptional corepressor with roles in the regulation of development, proliferation, and apoptosis [1].


  1. Interaction of MEQ protein and C-terminal-binding protein is critical for induction of lymphomas by Marek's disease virus. Brown, A.C., Baigent, S.J., Smith, L.P., Chattoo, J.P., Petherbridge, L.J., Hawes, P., Allday, M.J., Nair, V. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
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