Gene Review:
CTBP1 - C-terminal binding protein 1
Homo sapiens
Synonyms:
BARS, C-terminal-binding protein 1, CTBP, CtBP1
- Association of class I histone deacetylases with transcriptional corepressor CtBP. Subramanian, T., Chinnadurai, G. FEBS Lett. (2003)
- The expression levels of the transcriptional regulators p300 and CtBP modulate the correlations between SNAIL, ZEB1, E-cadherin and vitamin D receptor in human colon carcinomas. Peña, C., García, J.M., García, V., Silva, J., Domínguez, G., Rodríguez, R., Maximiano, C., García de Herreros, A., Muñoz, A., Bonilla, F. Int. J. Cancer (2006)
- The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes. Sierra, J., Yoshida, T., Joazeiro, C.A., Jones, K.A. Genes Dev. (2006)
- Redox sensor CtBP mediates hypoxia-induced tumor cell migration. Zhang, Q., Wang, S.Y., Nottke, A.C., Rocheleau, J.V., Piston, D.W., Goodman, R.H. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Interaction between a cellular protein that binds to the C-terminal region of adenovirus E1A (CtBP) and a novel cellular protein is disrupted by E1A through a conserved PLDLS motif. Schaeper, U., Subramanian, T., Lim, L., Boyd, J.M., Chinnadurai, G. J. Biol. Chem. (1998)
- Evaluation of quality of life and symptoms after translabyrinthine acoustic neuroma surgery. Andersson, G., Ekvall, L., Kinnefors, A., Nyberg, G., Rask-Andersen, H. The American journal of otology. (1997)
- The polycomb protein Pc2 is a SUMO E3. Kagey, M.H., Melhuish, T.A., Wotton, D. Cell (2003)
- Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP. Zhang, Q., Yoshimatsu, Y., Hildebrand, J., Frisch, S.M., Goodman, R.H. Cell (2003)
- Coordinated histone modifications mediated by a CtBP co-repressor complex. Shi, Y., Sawada, J., Sui, G., Affar, e.l. .B., Whetstine, J.R., Lan, F., Ogawa, H., Luke, M.P., Nakatani, Y., Shi, Y. Nature (2003)
- Acetylation at a lysine residue adjacent to the CtBP binding motif within adenovirus 12 E1A causes structural disruption and limited reduction of CtBP binding. Molloy, D., Mapp, K.L., Webster, R., Gallimore, P.H., Grand, R.J. Virology (2006)
- Identification of CtBP1 and CtBP2 as corepressors of zinc finger-homeodomain factor deltaEF1. Furusawa, T., Moribe, H., Kondoh, H., Higashi, Y. Mol. Cell. Biol. (1999)
- Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene. Alpatov, R., Munguba, G.C., Caton, P., Joo, J.H., Shi, Y., Shi, Y., Hunt, M.E., Sugrue, S.P. Mol. Cell. Biol. (2004)
- The leukemia-associated transcription repressor AML1/MDS1/EVI1 requires CtBP to induce abnormal growth and differentiation of murine hematopoietic cells. Senyuk, V., Chakraborty, S., Mikhail, F.M., Zhao, R., Chi, Y., Nucifora, G. Oncogene (2002)
- The transcriptional co-repressor C-terminal binding protein (CtBP) associates with centrosomes during mitosis. Spyer, M., Allday, M.J. Cell Cycle (2006)
- Expression of avian C-terminal binding proteins (Ctbp1 and Ctbp2) during embryonic development. Van Hateren, N., Shenton, T., Borycki, A.G. Dev. Dyn. (2006)
- The human candidate tumor suppressor gene HIC1 recruits CtBP through a degenerate GLDLSKK motif. Deltour, S., Pinte, S., Guerardel, C., Wasylyk, B., Leprince, D. Mol. Cell. Biol. (2002)
- Huntingtin is present in the nucleus, interacts with the transcriptional corepressor C-terminal binding protein, and represses transcription. Kegel, K.B., Meloni, A.R., Yi, Y., Kim, Y.J., Doyle, E., Cuiffo, B.G., Sapp, E., Wang, Y., Qin, Z.H., Chen, J.D., Nevins, J.R., Aronin, N., DiFiglia, M. J. Biol. Chem. (2002)
- Homeodomain-interacting protein kinase-2 mediates CtBP phosphorylation and degradation in UV-triggered apoptosis. Zhang, Q., Nottke, A., Goodman, R.H. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex. Zhang, Q., Wang, S.Y., Fleuriel, C., Leprince, D., Rocheleau, J.V., Piston, D.W., Goodman, R.H. Proc. Natl. Acad. Sci. U.S.A. (2007)
- A novel GATA factor transcriptionally represses yolk protein precursor genes in the mosquito Aedes aegypti via interaction with the CtBP corepressor. Martín, D., Piulachs, M.D., Raikhel, A.S. Mol. Cell. Biol. (2001)
- Phosphorylation of CtBP1 by cAMP-dependent protein kinase modulates induction of CYP17 by stimulating partnering of CtBP1 and 2. Dammer, E.B., Sewer, M.B. J. Biol. Chem. (2008)
- Changes in C-terminal Binding Protein 2 (CtBP2) Corepressor Complex Induced by E1A and Modulation of E1A Transcriptional Activity by CtBP2. Zhao, L.J., Subramanian, T., Chinnadurai, G. J. Biol. Chem. (2006)
- Corepressor CtBP1 interacts with and specifically inhibits CBP activity. Senyuk, V., Sinha, K.K., Nucifora, G. Arch. Biochem. Biophys. (2005)
- Regulation of subnuclear localization is associated with a mechanism for nuclear receptor corepression by RIP140. Tazawa, H., Osman, W., Shoji, Y., Treuter, E., Gustafsson, J.A., Zilliacus, J. Mol. Cell. Biol. (2003)
- The brain-specific actin-related protein ArpN alpha interacts with the transcriptional co-repressor CtBP. Oma, Y., Nishimori, K., Harata, M. Biochem. Biophys. Res. Commun. (2003)
- Multiple activities contribute to Pc2 E3 function. Kagey, M.H., Melhuish, T.A., Powers, S.E., Wotton, D. EMBO J. (2005)
- Opposed regulation of corepressor CtBP by SUMOylation and PDZ binding. Lin, X., Sun, B., Liang, M., Liang, Y.Y., Gast, A., Hildebrand, J., Brunicardi, F.C., Melchior, F., Feng, X.H. Mol. Cell (2003)
- Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity. Koipally, J., Georgopoulos, K. J. Biol. Chem. (2000)
- A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP. Stankovic-Valentin, N., Verger, A., Deltour-Balerdi, S., Quinlan, K.G., Crossley, M., Leprince, D. FEBS J. (2006)
- A novel C-terminal binding protein (CTBP2) is closely related to CTBP1, an adenovirus E1A-binding protein, and maps to human chromosome 21q21.3. Katsanis, N., Fisher, E.M. Genomics (1998)
- Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor. Yu, X., Baer, R. J. Biol. Chem. (2000)
- Multiple domains of the Receptor-Interacting Protein 140 contribute to transcription inhibition. Castet, A., Boulahtouf, A., Versini, G., Bonnet, S., Augereau, P., Vignon, F., Khochbin, S., Jalaguier, S., Cavaillès, V. Nucleic Acids Res. (2004)