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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

RAG1  -  recombination activating gene 1

Gallus gallus

 
 
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High impact information on RAG1

  • Therefore, we have examined the potential role of the V(D)J recombination activating genes, RAG-1 and RAG-2, in regulating chicken Ig gene conversion [1].
  • The single-copy RAG-1 gene is found throughout higher vertebrates and consists of a single 3.1-kb exon without intervening introns [2].
  • RAG-1 evolves slowly, with a number of properties favoring its phylogenetic utility, including rarity of indels, minimal saturation of transition changes at 3rd positions of codons, nearly constant base composition across taxa, and no asymmetry in directional patterns of reconstructed change [2].
 

Anatomical context of RAG1

  • The recombinase-activating genes, RAG-1 and RAG-2, have been shown to be necessary to initiate the process of V(D)J recombination during the ontogeny of lymphocytes [3].
 

Other interactions of RAG1

  • We found that the CD43+IgM- and double-negative CD43-IgM- cells contained RAG1 transcripts and RAG2 protein [4].

References

  1. Selective expression of RAG-2 in chicken B cells undergoing immunoglobulin gene conversion. Carlson, L.M., Oettinger, M.A., Schatz, D.G., Masteller, E.L., Hurley, E.A., McCormack, W.T., Baltimore, D., Thompson, C.B. Cell (1991) [Pubmed]
  2. Basal divergences in birds and the phylogenetic utility of the nuclear RAG-1 gene. Groth, J.G., Barrowclough, G.F. Mol. Phylogenet. Evol. (1999) [Pubmed]
  3. Regulation of RAG-2 protein expression in avian thymocytes. Ferguson, S.E., Accavitti, M.A., Wang, D.D., Chen, C.L., Thompson, C.B. Mol. Cell. Biol. (1994) [Pubmed]
  4. RAG1 and RAG2 in developing rabbit appendix subpopulations. Fuschiotti, P., Fitts, M.G., Pospisil, R., Weinstein, P.D., Mage, R.G. J. Immunol. (1997) [Pubmed]
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