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Gene Review:

RAG2 - recombination activating gene 2

Gallus gallus

Carlson, L.M. et al., Ferguson, S.E. et al., Fuschiotti, P. et al., Kawahata, K. et al.

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High impact information on RAG2

Therefore, we have examined the potential role of the V(D)J recombination activating genes, RAG-1 and RAG-2, in regulating chicken Ig gene conversion [1].
Selective expression of RAG-2 in chicken B cells undergoing immunoglobulin gene conversion [1].
These data suggest that RAG-2 plays a fundamental role in Ig-specific gene conversion [1].
Mitogenic stimulation of thymocytes with phorbol myristate acetate and ionomycin results in down-regulation of RAG-2 expression [2].
Down-regulation of RAG-2 expression appears to occur before cells enter S phase, suggesting that RAG-2 function may be limited to noncycling cells [2].

Anatomical context of RAG2

We detected RAG2 protein in the four subpopulations of rabbit appendix lymphocytes, distinguished by surface CD43 and IgM markers [3].
In contrast, in DO11.10 mice, CD4(+)CD25(+) T cells expressed endogenous TCR alpha beta chains, which disappeared in recombination-activating gene 2-deficient DO11.10 mice [4].

Other interactions of RAG2

We found that the CD43+IgM- and double-negative CD43-IgM- cells contained RAG1 transcripts and RAG2 protein [3].

References

Selective expression of RAG-2 in chicken B cells undergoing immunoglobulin gene conversion. Carlson, L.M., Oettinger, M.A., Schatz, D.G., Masteller, E.L., Hurley, E.A., McCormack, W.T., Baltimore, D., Thompson, C.B. Cell (1991) [Pubmed]
Regulation of RAG-2 protein expression in avian thymocytes. Ferguson, S.E., Accavitti, M.A., Wang, D.D., Chen, C.L., Thompson, C.B. Mol. Cell. Biol. (1994) [Pubmed]
RAG1 and RAG2 in developing rabbit appendix subpopulations. Fuschiotti, P., Fitts, M.G., Pospisil, R., Weinstein, P.D., Mage, R.G. J. Immunol. (1997) [Pubmed]
Generation of CD4(+)CD25(+) regulatory T cells from autoreactive T cells simultaneously with their negative selection in the thymus and from nonautoreactive T cells by endogenous TCR expression. Kawahata, K., Misaki, Y., Yamauchi, M., Tsunekawa, S., Setoguchi, K., Miyazaki, J., Yamamoto, K. J. Immunol. (2002) [Pubmed]

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