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Gene Review

rag1  -  recombination activating gene 1

Danio rerio

Synonyms: RAG-1, SO:0000704, V(D)J recombination-activating protein 1
 
 
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High impact information on rag1

 

Biological context of rag1

 

Anatomical context of rag1

 

Associations of rag1 with chemical compounds

  • Parental fish were mutagenized with N-ethyl-N-nitrosourea; in 2679 F1 fish, the rag1 gene was analyzed for heterozygous mutations by resequencing [8].
 

Other interactions of rag1

  • The closely linked recombination activating genes, rag1 and rag2, encode components of the recombinase involved in V(D)J recombination of the immunoglobulin and T-cell receptor genes [5].

References

  1. Artificial chromosome transgenesis reveals long-distance negative regulation of rag1 in zebrafish. Jessen, J.R., Willett, C.E., Lin, S. Nat. Genet. (1999) [Pubmed]
  2. Tracing Hematopoietic Precursor Migration to Successive Hematopoietic Organs during Zebrafish Development. Murayama, E., Kissa, K., Zapata, A., Mordelet, E., Briolat, V., Lin, H.F., Handin, R.I., Herbomel, P. Immunity (2006) [Pubmed]
  3. B cells develop in the zebrafish pancreas. Danilova, N., Steiner, L.A. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  4. Expression of zebrafish rag genes during early development identifies the thymus. Willett, C.E., Zapata, A.G., Hopkins, N., Steiner, L.A. Dev. Biol. (1997) [Pubmed]
  5. Characterization and expression of the recombination activating genes (rag1 and rag2) of zebrafish. Willett, C.E., Cherry, J.J., Steiner, L.A. Immunogenetics (1997) [Pubmed]
  6. Concurrent expression of recombination activating genes 1 and 2 in zebrafish olfactory sensory neurons. Jessen, J.R., Jessen, T.N., Vogel, S.S., Lin, S. Genesis (2001) [Pubmed]
  7. The recombination activation gene 1 (Rag1) is expressed in a subset of zebrafish olfactory neurons but is not essential for axon targeting or amino acid detection. Feng, B., Bulchand, S., Yaksi, E., Friedrich, R.W., Jesuthasan, S. BMC neuroscience [electronic resource]. (2005) [Pubmed]
  8. Target-selected inactivation of the zebrafish rag1 gene. Wienholds, E., Schulte-Merker, S., Walderich, B., Plasterk, R.H. Science (2002) [Pubmed]
 
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