The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

rag1  -  recombination activating gene 1

Danio rerio

Synonyms: RAG-1, SO:0000704, V(D)J recombination-activating protein 1
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on rag1


Biological context of rag1


Anatomical context of rag1


Associations of rag1 with chemical compounds

  • Parental fish were mutagenized with N-ethyl-N-nitrosourea; in 2679 F1 fish, the rag1 gene was analyzed for heterozygous mutations by resequencing [8].

Other interactions of rag1

  • The closely linked recombination activating genes, rag1 and rag2, encode components of the recombinase involved in V(D)J recombination of the immunoglobulin and T-cell receptor genes [5].


  1. Artificial chromosome transgenesis reveals long-distance negative regulation of rag1 in zebrafish. Jessen, J.R., Willett, C.E., Lin, S. Nat. Genet. (1999) [Pubmed]
  2. Tracing Hematopoietic Precursor Migration to Successive Hematopoietic Organs during Zebrafish Development. Murayama, E., Kissa, K., Zapata, A., Mordelet, E., Briolat, V., Lin, H.F., Handin, R.I., Herbomel, P. Immunity (2006) [Pubmed]
  3. B cells develop in the zebrafish pancreas. Danilova, N., Steiner, L.A. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  4. Expression of zebrafish rag genes during early development identifies the thymus. Willett, C.E., Zapata, A.G., Hopkins, N., Steiner, L.A. Dev. Biol. (1997) [Pubmed]
  5. Characterization and expression of the recombination activating genes (rag1 and rag2) of zebrafish. Willett, C.E., Cherry, J.J., Steiner, L.A. Immunogenetics (1997) [Pubmed]
  6. Concurrent expression of recombination activating genes 1 and 2 in zebrafish olfactory sensory neurons. Jessen, J.R., Jessen, T.N., Vogel, S.S., Lin, S. Genesis (2001) [Pubmed]
  7. The recombination activation gene 1 (Rag1) is expressed in a subset of zebrafish olfactory neurons but is not essential for axon targeting or amino acid detection. Feng, B., Bulchand, S., Yaksi, E., Friedrich, R.W., Jesuthasan, S. BMC neuroscience [electronic resource]. (2005) [Pubmed]
  8. Target-selected inactivation of the zebrafish rag1 gene. Wienholds, E., Schulte-Merker, S., Walderich, B., Plasterk, R.H. Science (2002) [Pubmed]
WikiGenes - Universities