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Gene Review:

MFNG - MFNG O-fucosylpeptide 3-beta-N...

Homo sapiens

Synonyms: Beta-1,3-N-acetylglucosaminyltransferase manic fringe, O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

May, W.A. et al., Xu, Y. et al., Van Tine, B.A. et al., Egan, S. et al.

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Disease relevance of MFNG

Overexpression of MFNG in NIH 3T3 cells renders them tumorigenic in mice with severe combined immunodeficiency disease (SCID) [1].

High impact information on MFNG

We have found that EWS/FLI1 and structurally related fusion proteins upregulate manic fringe (MFNG), a recently described member of the Fringe gene family instrumental in somatic development [1].
MFNG is also expressed in human tumour-derived cell lines expressing EWS/FLI1 [1].
Furthermore, ectopic Mfng expression induces the expression of basic helix-loop-helix gene, Ngn3, and two zinc finger genes, cMyt1 and cMyt3 [2].
Using chicken embryonic endoderm as an assaying system, we found that ectopic Mfng expression is sufficient to induce endodermal cells to differentiate towards an endocrine fate [2].
Mapping of the human Lunatic Fringe (LFNG) gene to 7p22 and Manic Fringe (MFNG) to 22q12 [3].

Analytical, diagnostic and therapeutic context of MFNG

Assignment of human MFNG, manic fringe Drosophila homolog, to 22q13.1 using tyramide fluorescence in situ hybridization (T-FISH) [4].

References

EWS/FLI1-induced manic fringe renders NIH 3T3 cells tumorigenic. May, W.A., Arvand, A., Thompson, A.D., Braun, B.S., Wright, M., Denny, C.T. Nat. Genet. (1997) [Pubmed]
The fringe molecules induce endocrine differentiation in embryonic endoderm by activating cMyt1/cMyt3. Xu, Y., Wang, S., Zhang, J., Zhao, A., Stanger, B.Z., Gu, G. Dev. Biol. (2006) [Pubmed]
Mapping of the human Lunatic Fringe (LFNG) gene to 7p22 and Manic Fringe (MFNG) to 22q12. Egan, S., Herbrick, J.A., Tsui, L.C., Cohen, B., Flock, G., Beatty, B., Scherer, S.W. Genomics (1998) [Pubmed]
Assignment of human MFNG, manic fringe Drosophila homolog, to 22q13.1 using tyramide fluorescence in situ hybridization (T-FISH). Van Tine, B.A., Knops, J., Shaw, G.M., May, W.A. Cytogenet. Cell Genet. (1999) [Pubmed]

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