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Gene Review

LFNG  -  LFNG O-fucosylpeptide 3-beta-N...

Homo sapiens

Synonyms: Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe, O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase, SCDO3
 
 
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High impact information on LFNG

  • LFNG encodes a glycosyltransferase that modifies the Notch family of cell-surface receptors, a key step in the regulation of this signaling pathway [1].
  • Thus, we examined whether such change of expression of Lfng plays a role in T cell development [2].
  • In contrast, the down-regulation of Lfng in thymocytes suppressed DP cells development due to the defective transition from CD44(+)CD25(-) stage to subsequent stage in DN cells [2].
  • The overexpression of Lfng in fetal liver-derived hemopoietic stem cells enhanced T cell development, whereas its down-regulation suppressed it [2].
  • Mapping of the human Lunatic Fringe (LFNG) gene to 7p22 and Manic Fringe (MFNG) to 22q12 [3].
 

Biological context of LFNG

 

Anatomical context of LFNG

  • These independent Lfng regulatory cassettes advance a molecular framework for deciphering somite segmentation [4].
  • Lunatic fringe (Lfng) expression in the presomitic mesoderm (PSM) cycles in the posterior PSM, is refined in the segmenting somite to the rostral compartment, and is required for segmentation [4].
 

Regulatory relationships of LFNG

  • These results suggested that the physiological high expression of Lfng in DN cells contributes to enhance T cell differentiation through strengthening Notch signaling [2].

References

  1. Mutation of the LUNATIC FRINGE gene in humans causes spondylocostal dysostosis with a severe vertebral phenotype. Sparrow, D.B., Chapman, G., Wouters, M.A., Whittock, N.V., Ellard, S., Fatkin, D., Turnpenny, P.D., Kusumi, K., Sillence, D., Dunwoodie, S.L. Am. J. Hum. Genet. (2006) [Pubmed]
  2. Lunatic Fringe Controls T Cell Differentiation through Modulating Notch Signaling. Tsukumo, S., Hirose, K., Maekawa, Y., Kishihara, K., Yasutomo, K. J. Immunol. (2006) [Pubmed]
  3. Mapping of the human Lunatic Fringe (LFNG) gene to 7p22 and Manic Fringe (MFNG) to 22q12. Egan, S., Herbrick, J.A., Tsui, L.C., Cohen, B., Flock, G., Beatty, B., Scherer, S.W. Genomics (1998) [Pubmed]
  4. Clock regulatory elements control cyclic expression of Lunatic fringe during somitogenesis. Cole, S.E., Levorse, J.M., Tilghman, S.M., Vogt, T.F. Dev. Cell (2002) [Pubmed]
 
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