Gene Review:
EWSR1 - EWS RNA-binding protein 1
Homo sapiens
Synonyms:
EWS, EWS oncogene, Ewing sarcoma breakpoint region 1 protein, RNA-binding protein EWS, bK984G1.4
Nishio,
Iwasaki,
Ishiguro,
Ohjimi,
Isayama,
Naito,
Kaneko,
Kamada,
Kikuchi,
Panagopoulos,
Mertens,
Dêbiec-Rychter,
Isaksson,
Limon,
Kardas,
Domanski,
Sciot,
Perek,
Crnalic,
Larsson,
Mandahl,
Panagopoulos,
Mertens,
Isaksson,
Mandahl,
Hallor,
Mertens,
Jin,
Meis-Kindblom,
Kindblom,
Behrendtz,
Kalén,
Mandahl,
Panagopoulos,
- Expression profiling of t(12;22) positive clear cell sarcoma of soft tissue cell lines reveals characteristic up-regulation of potential new marker genes including ERBB3. Schaefer, K.L., Brachwitz, K., Wai, D.H., Braun, Y., Diallo, R., Korsching, E., Eisenacher, M., Voss, R., Van Valen, F., Baer, C., Selle, B., Spahn, L., Liao, S.K., Lee, K.A., Hogendoorn, P.C., Reifenberger, G., Gabbert, H.E., Poremba, C. Cancer Res. (2004)
- Fusion of the EWSR1 and ATF1 genes without expression of the MITF-M transcript in angiomatoid fibrous histiocytoma. Hallor, K.H., Mertens, F., Jin, Y., Meis-Kindblom, J.M., Kindblom, L.G., Behrendtz, M., Kalén, A., Mandahl, N., Panagopoulos, I. Genes Chromosomes Cancer (2005)
- Absence of mutations of the BRAF gene in malignant melanoma of soft parts (clear cell sarcoma of tendons and aponeuroses). Panagopoulos, I., Mertens, F., Isaksson, M., Mandahl, N. Cancer Genet. Cytogenet. (2005)
- EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts. Zucman, J., Delattre, O., Desmaze, C., Epstein, A.L., Stenman, G., Speleman, F., Fletchers, C.D., Aurias, A., Thomas, G. Nat. Genet. (1993)
- "The future should not take us by surprise": preparation of an early warning system in Denmark. Douw, K., Vondeling, H., Sørensen, J., Jørgensen, T., Sigmund, H. International journal of technology assessment in health care. (2004)
- Development and preliminary validation of the testable assumptions questionnaire--eating disorders (TAQ-ED). Hinrichsen, H., Garry, J., Waller, G. Eating behaviors. (2006)
- Repression of the gene encoding the TGF-beta type II receptor is a major target of the EWS-FLI1 oncoprotein. Hahm, K.B., Cho, K., Lee, C., Im, Y.H., Chang, J., Choi, S.G., Sorensen, P.H., Thiele, C.J., Kim, S.J. Nat. Genet. (1999)
- EWS/FLI1-induced manic fringe renders NIH 3T3 cells tumorigenic. May, W.A., Arvand, A., Thompson, A.D., Braun, B.S., Wright, M., Denny, C.T. Nat. Genet. (1997)
- Interaction of the EWS NH2 terminus with BARD1 links the Ewing's sarcoma gene to a common tumor suppressor pathway. Spahn, L., Petermann, R., Siligan, C., Schmid, J.A., Aryee, D.N., Kovar, H. Cancer Res. (2002)
- Exposure on cell surface and extensive arginine methylation of ewing sarcoma (EWS) protein. Belyanskaya, L.L., Gehrig, P.M., Gehring, H. J. Biol. Chem. (2001)
- Fusion of the EWS gene to CHN, a member of the steroid/thyroid receptor gene superfamily, in a human myxoid chondrosarcoma. Clark, J., Benjamin, H., Gill, S., Sidhar, S., Goodwin, G., Crew, J., Gusterson, B.A., Shipley, J., Cooper, C.S. Oncogene (1996)
- A practical approach to the clinical diagnosis of Ewing's sarcoma/primitive neuroectodermal tumour and other small round cell tumours sharing EWS rearrangement using new fluorescence in situ hybridisation probes for EWSR1 on formalin fixed, paraffin wax embedded tissue. Yamaguchi, U., Hasegawa, T., Morimoto, Y., Tateishi, U., Endo, M., Nakatani, F., Kawai, A., Chuman, H., Beppu, Y., Endo, M., Kurotaki, H., Furuta, K. J. Clin. Pathol. (2005)
- A repetitive element containing a critical tyrosine residue is required for transcriptional activation by the EWS/ATF1 oncogene. Feng, L., Lee, K.A. Oncogene (2001)
- Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours. Delattre, O., Zucman, J., Plougastel, B., Desmaze, C., Melot, T., Peter, M., Kovar, H., Joubert, I., de Jong, P., Rouleau, G. Nature (1992)
- EWSR1 is fused to POU5F1 in a bone tumor with translocation t(6;22)(p21;q12). Yamaguchi, S., Yamazaki, Y., Ishikawa, Y., Kawaguchi, N., Mukai, H., Nakamura, T. Genes Chromosomes Cancer (2005)
- Synovial sarcoma with a secondary chromosome change der(22)t(17;22)(q12;q12). Nishio, J., Iwasaki, H., Ishiguro, M., Ohjimi, Y., Isayama, T., Naito, M., Kaneko, Y., Kamada, N., Kikuchi, M. Cancer Genet. Cytogenet. (2002)
- Arrangement of chromosome 11 and 22 territories, EWSR1 and FLI1 genes, and other genetic elements of these chromosomes in human lymphocytes and Ewing sarcoma cells. Taslerová, R., Kozubek, S., Lukásová, E., Jirsová, P., Bártová, E., Kozubek, M. Hum. Genet. (2003)
- Expression of the FUS-CHOP fusion protein in primary mesenchymal progenitor cells gives rise to a model of myxoid liposarcoma. Riggi, N., Cironi, L., Provero, P., Suvà, M.L., Stehle, J.C., Baumer, K., Guillou, L., Stamenkovic, I. Cancer Res. (2006)
- Cooperative interaction of EWS with CREB-binding protein selectively activates hepatocyte nuclear factor 4-mediated transcription. Araya, N., Hirota, K., Shimamoto, Y., Miyagishi, M., Yoshida, E., Ishida, J., Kaneko, S., Kaneko, M., Nakajima, T., Fukamizu, A. J. Biol. Chem. (2003)
- The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription. Zhang, D., Paley, A.J., Childs, G. J. Biol. Chem. (1998)
- The SH3 domain of Bruton's tyrosine kinase interacts with Vav, Sam68 and EWS. Guinamard, R., Fougereau, M., Seckinger, P. Scand. J. Immunol. (1997)
- The COOH-terminal domain of FLI-1 is necessary for full tumorigenesis and transcriptional modulation by EWS/FLI-1. Arvand, A., Welford, S.M., Teitell, M.A., Denny, C.T. Cancer Res. (2001)
- Tyrosine kinase Pyk2 mediates G-protein-coupled receptor regulation of the Ewing sarcoma RNA-binding protein EWS. Felsch, J.S., Lane, W.S., Peralta, E.G. Curr. Biol. (1999)
- A new member of the ETS family fused to EWS in Ewing tumors. Peter, M., Couturier, J., Pacquement, H., Michon, J., Thomas, G., Magdelenat, H., Delattre, O. Oncogene (1997)
- Oncogenic EWS-Fli1 interacts with hsRPB7, a subunit of human RNA polymerase II. Petermann, R., Mossier, B.M., Aryee, D.N., Khazak, V., Golemis, E.A., Kovar, H. Oncogene (1998)
- Modulation of EWS/WT1 activity by the v-Src protein tyrosine kinase. Kim, J., Lee, J.M., Branton, P.E., Pelletier, J. FEBS Lett. (2000)
- STAT3 is activated in a subset of the Ewing sarcoma family of tumours. Lai, R., Navid, F., Rodriguez-Galindo, C., Liu, T., Fuller, C.E., Ganti, R., Dien, J., Dalton, J., Billups, C., Khoury, J.D. J. Pathol. (2006)
- EWS/ETS fusions activate telomerase in Ewing's tumors. Takahashi, A., Higashino, F., Aoyagi, M., Yoshida, K., Itoh, M., Kyo, S., Ohno, T., Taira, T., Ariga, H., Nakajima, K., Hatta, M., Kobayashi, M., Sano, H., Kohgo, T., Shindoh, M. Cancer Res. (2003)
- The splicing factor U1C represses EWS/FLI-mediated transactivation. Knoop, L.L., Baker, S.J. J. Biol. Chem. (2000)
- Insulin-like growth factor binding protein 3 as an anticancer molecule in Ewing's sarcoma. Benini, S., Zuntini, M., Manara, M.C., Cohen, P., Nicoletti, G., Nanni, P., Oh, Y., Picci, P., Scotlandi, K. Int. J. Cancer (2006)
- Transactivation of cyclin E gene by EWS-Fli1 and antitumor effects of cyclin dependent kinase inhibitor on Ewing's family tumor cells. Li, X., Tanaka, K., Nakatani, F., Matsunobu, T., Sakimura, R., Hanada, M., Okada, T., Nakamura, T., Iwamoto, Y. Int. J. Cancer (2005)
- EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3. Prieur, A., Tirode, F., Cohen, P., Delattre, O. Mol. Cell. Biol. (2004)
- EWS-FLI1, EWS-ERG, and EWS-ETV1 oncoproteins of Ewing tumor family all suppress transcription of transforming growth factor beta type II receptor gene. Im, Y.H., Kim, H.T., Lee, C., Poulin, D., Welford, S., Sorensen, P.H., Denny, C.T., Kim, S.J. Cancer Res. (2000)
- Inhibition of platelet-derived growth factor-induced cell growth signaling by a short interfering RNA for EWS-Fli1 via down-regulation of phospholipase D2 in Ewing sarcoma cells. Nozawa, S., Ohno, T., Banno, Y., Dohjima, T., Wakahara, K., Fan, D.G., Shimizu, K. J. Biol. Chem. (2005)
- A novel zinc finger gene is fused to EWS in small round cell tumor. Mastrangelo, T., Modena, P., Tornielli, S., Bullrich, F., Testi, M.A., Mezzelani, A., Radice, P., Azzarelli, A., Pilotti, S., Croce, C.M., Pierotti, M.A., Sozzi, G. Oncogene (2000)
- Esophageal extraskeletal Ewing's sarcoma. Maesawa, C., Iijima, S., Sato, N., Yoshinori, N., Suzuki, M., Tarusawa, M., Ishida, K., Tamura, G., Saito, K., Masuda, T. Hum. Pathol. (2002)
- Induction of the interleukin-2/15 receptor beta-chain by the EWS-WT1 translocation product. Wong, J.C., Lee, S.B., Bell, M.D., Reynolds, P.A., Fiore, E., Stamenkovic, I., Truong, V., Oliner, J.D., Gerald, W.L., Haber, D.A. Oncogene (2002)
- Molecular genetic characterization of the EWS/ATF1 fusion gene in clear cell sarcoma of tendons and aponeuroses. Panagopoulos, I., Mertens, F., Dêbiec-Rychter, M., Isaksson, M., Limon, J., Kardas, I., Domanski, H.A., Sciot, R., Perek, D., Crnalic, S., Larsson, O., Mandahl, N. Int. J. Cancer (2002)