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Gene Review: 

Calx  -  Na/Ca-exchange protein

Drosophila melanogaster

Synonyms: 9C5, CALX, CALX1.1, CG5685, CalX, ...
 
 
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High impact information on Calx

  • The Calx genomic locus comprises >/=35 kb between the Atpalpha and rudimentary-like genes in chromosomal region 93B [1].
  • In Xenopus oocytes, microinjected Calx cRNA induces calcium uptake like that of its homolog, the 3Na+-1Ca2+ exchanger of mammalian heart [1].
  • Structure-function analysis of CALX1.1, a Na+-Ca2+ exchanger from Drosophila. Mutagenesis of ionic regulatory sites [2].
  • Similarly, mutations within the putative XIP region of CALX1.1, as in NCX1.1, led to two distinct phenotypes: acceleration (i.e. K306Q) and elimination (i.e. Delta310-313) of Na+i-dependent inactivation [2].
  • With one chimera (i.e. CALX:NCX:CALX), substitution of a 193-amino acid segment, from the large intracellular loop of NCX1.1, for the corresponding 177-amino acid segment of CALX1.1 led to an exchanger that was stimulated by Ca2+i. This result indicates that the regulatory Ca2+i binding site of NCX1.1 retains function in a CALX1 [2].
 

Biological context of Calx

  • These exchangers, designated CALX1.1 and CALX1.2, differ by five amino acids in a region where alternative splicing also occurs in the mammalian Na+-Ca2+ exchanger, NCX1 [3].
 

Anatomical context of Calx

  • In analogy to similar studies conduced in the honeybee drone, we suggest that the reduction in [Ca2+]o reflects light-induced Ca2+ influx into the photoreceptors, while the subsequent increase in [Ca2+]o reflects the activation of the Na-Ca exchange which extrudes Ca2+ from the cells [4].
 

Associations of Calx with chemical compounds

  • The electrophysiological effects of the benzothiazepine 7-chloro-3,5-dihydro-5-phenyl-1H-4,1-benzothiazepine-2-one (CGP-37157) (CGP) were investigated on the canine (NCX1.1) and Drosophila (CALX1.1) plasmalemmal Na+-Ca2+ exchangers [5].

References

  1. Calx, a Na-Ca exchanger gene of Drosophila melanogaster. Schwarz, E.M., Benzer, S. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  2. Structure-function analysis of CALX1.1, a Na+-Ca2+ exchanger from Drosophila. Mutagenesis of ionic regulatory sites. Dyck, C., Maxwell, K., Buchko, J., Trac, M., Omelchenko, A., Hnatowich, M., Hryshko, L.V. J. Biol. Chem. (1998) [Pubmed]
  3. Functional differences in ionic regulation between alternatively spliced isoforms of the Na+-Ca2+ exchanger from Drosophila melanogaster. Omelchenko, A., Dyck, C., Hnatowich, M., Buchko, J., Nicoll, D.A., Philipson, K.D., Hryshko, L.V. J. Gen. Physiol. (1998) [Pubmed]
  4. The nss mutation or lanthanum inhibits light-induced Ca2+ influx into fly photoreceptors. Rom-Glas, A., Sandler, C., Kirschfeld, K., Minke, B. J. Gen. Physiol. (1992) [Pubmed]
  5. Inhibition of canine (NCX1.1) and Drosophila (CALX1.1) Na(+)-Ca(2+) exchangers by 7-chloro-3,5-dihydro-5-phenyl-1H-4,1-benzothiazepine-2-one (CGP-37157). Omelchenko, A., Bouchard, R., Le, H.D., Choptiany, P., Visen, N., Hnatowich, M., Hryshko, L.V. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
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