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Atpalpha  -  Na pump alpha subunit

Drosophila melanogaster

Synonyms: ATP-alpha, ATPBagr, ATPa, ATPalpha, Atp a, ...
 
 
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High impact information on Atpalpha

  • The Calx genomic locus comprises >/=35 kb between the Atpalpha and rudimentary-like genes in chromosomal region 93B [1].
  • Strikingly, the rat alpha1 isoform has full junctional activity and can rescue Atpalpha-null mutants to viability, suggesting that the Na,K-ATPase has an evolutionarily conserved role in junction formation and function [2].
  • The heterodimeric Na,K-ATPase has been implicated in vertebrate and invertebrate epithelial cell junctions, morphogenesis and oncogenesis, but the mechanisms involved are unclear [2].
  • Regulation of the Na-K-ATPase beta(1)-subunit promoter by multiple prostaglandin-responsive elements [3].
  • In this report, we present evidence from EMSAs and DNA affinity precipitation studies that another PGRE present in the Na-K-ATPase beta(1)-subunit promoter similarly binds CREB and Sp1 [3].
 

Biological context of Atpalpha

 

Anatomical context of Atpalpha

 

Analytical, diagnostic and therapeutic context of Atpalpha

References

  1. Calx, a Na-Ca exchanger gene of Drosophila melanogaster. Schwarz, E.M., Benzer, S. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  2. A pump-independent function of the Na,K-ATPase is required for epithelial junction function and tracheal tube-size control. Paul, S.M., Palladino, M.J., Beitel, G.J. Development (2007) [Pubmed]
  3. Regulation of the Na-K-ATPase beta(1)-subunit promoter by multiple prostaglandin-responsive elements. Matlhagela, K., Taub, M. Am. J. Physiol. Renal Physiol. (2006) [Pubmed]
  4. Functional analysis and tissue-specific expression of Drosophila Na+,K+-ATPase subunits. Sun, B., Wang, W., Salvaterra, P.M. J. Neurochem. (1998) [Pubmed]
  5. Neural dysfunction and neurodegeneration in Drosophila Na+/K+ ATPase alpha subunit mutants. Palladino, M.J., Bower, J.E., Kreber, R., Ganetzky, B. J. Neurosci. (2003) [Pubmed]
  6. Na-K-ATPase regulates tight junction permeability through occludin phosphorylation in pancreatic epithelial cells. Rajasekaran, S.A., Barwe, S.P., Gopal, J., Ryazantsev, S., Schneeberger, E.E., Rajasekaran, A.K. Am. J. Physiol. Gastrointest. Liver Physiol. (2007) [Pubmed]
  7. Cellular bases of activity-dependent paralysis in Drosophila stress-sensitive mutants. Trotta, N., Rodesch, C.K., Fergestad, T., Broadie, K. J. Neurobiol. (2004) [Pubmed]
  8. Molecular cloning of the Na,K-ATPase alpha-subunit in developing brine shrimp and sequence comparison with higher organisms. Baxter-Lowe, L.A., Guo, J.Z., Bergstrom, E.E., Hokin, L.E. FEBS Lett. (1989) [Pubmed]
 
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