Gene Review:
ccne1 - cyclin E1
Danio rerio
Synonyms:
G1/S-specific cyclin-E1, SO:0000704, ccne, cyce, fa18e07, ...
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High impact information on ccne
- These results suggest an additional role for cyclin E during early embryogenesis, in addition to its established role during the G1/S transition in somatic cells [1].
- During the rapid cell cycles of the early cleavage stage, which lacks a G1 phase, the cyclin E mRNA, protein, and associated H1 kinase activity were found to be constitutive, in contrast to their reported cyclic behavior during the cycle of cultured mammalian cells [1].
- Cyclin E mRNA was reduced during epiboly (approximately 6-8 hr postfertilization, HPF), concomitantly with a marked reduction in cell division rates [1].
Biological context of ccne
- Cyclin E cDNA, cloned from a zebrafish embryonic cDNA library, was used for analysis of cyclin E regulation during early embryogenesis [1].
References
- Zebrafish cyclin E regulation during early embryogenesis. Yarden, A., Geiger, B. Dev. Dyn. (1996) [Pubmed]
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