Gene Review:
Ccne1 - cyclin E1
Rattus norvegicus
Synonyms:
CYCLE, Ccne, G1/S-specific cyclin-E1
- The oncogenic activity of cyclin E is not confined to Cdk2 activation alone but relies on several other, distinct functions of the protein. Geisen, C., Moroy, T. J. Biol. Chem. (2002)
- Overexpression of protein kinase G using adenovirus inhibits cyclin E transcription and mesangial cell cycle. Hanada, S., Terada, Y., Inoshita, S., Sasaki, S., Lohmann, S.M., Smolenski, A., Marumo, F. Am. J. Physiol. Renal Physiol. (2001)
- Aberrant expression of p27(Kip1) is associated with malignant transformation of the rat urinary bladder epithelium. Ogawa, K., Kimoto, N., Asamoto, M., Nakanishi, M., Takahashi, S., Shirai, T. Carcinogenesis (2000)
- Lower activity of CCAAT/enhancer-binding protein and expression of cyclin E, but not cyclin D1, activating protein-1 and p21(WAF1), after partial hepatectomy in obstructive jaundice. Nakano, K., Chijiiwa, K., Tanaka, M. Biochem. Biophys. Res. Commun. (2001)
- Inhibition of DNA synthesis by RB: effects on G1/S transition and S-phase progression. Knudsen, E.S., Buckmaster, C., Chen, T.T., Feramisco, J.R., Wang, J.Y. Genes Dev. (1998)
- A K-ras oncogene increases resistance to sulindac-induced apoptosis in rat enterocytes. Arber, N., Han, E.K., Sgambato, A., Piazza, G.A., Delohery, T.M., Begemann, M., Weghorst, C.M., Kim, N.H., Pamukcu, R., Ahnen, D.J., Reed, J.C., Weinstein, I.B., Holt, P.R. Gastroenterology (1997)
- E1A can provoke G1 exit that is refractory to p21 and independent of activating cdk2. Akli, S., Zhan, S., Abdellatif, M., Schneider, M.D. Circ. Res. (1999)
- Ectopic expression of cyclin D1 but not cyclin E induces anchorage-independent cell cycle progression. Resnitzky, D. Mol. Cell. Biol. (1997)
- Dehydroepiandrosterone causes hyperplasia and impairs regeneration in rat liver. Kopplow, K., Wayss, K., Enzmann, H., Mayer, D. Int. J. Oncol. (2005)
- Long-term 17alpha-ethinyl estradiol treatment decreases cyclin E and cdk2 expression, reduces cdk2 kinase activity and inhibits S phase entry in regenerating rat liver. Koroxenidou, L., Ohlson, L.C., Porsch Hällström, I. J. Hepatol. (2005)
- Lack of intestinal bile results in delayed liver regeneration of normal rat liver after hepatectomy accompanied by impaired cyclin E-associated kinase activity. Ueda, J., Chijiiwa, K., Nakano, K., Zhao, G., Tanaka, M. Surgery (2002)
- Basic fibroblast growth factor exhibits dual and rapid regulation of cyclin D1 and p27 to stimulate proliferation of rat cerebral cortical precursors. Li, B., DiCicco-Bloom, E. Dev. Neurosci. (2004)
- A centrosomal localization signal in cyclin E required for Cdk2-independent S phase entry. Matsumoto, Y., Maller, J.L. Science (2004)
- Synergistic gene expressions of cyclin E, cdk2, cdk5 and E2F-1 during the prolactin-induced G1/S transition in rat Nb2 pre-T lymphoma cells. Hosokawa, Y., Yang, M., Kaneko, S., Tanaka, M., Nakashima, K. Biochem. Mol. Biol. Int. (1995)
- Activation of cyclin-dependent kinase 2 (Cdk2) in growth-stimulated rat astrocytes. Geranylgeranylated Rho small GTPase(s) are essential for the induction of cyclin E gene expression. Tanaka, T., Tatsuno, I., Noguchi, Y., Uchida, D., Oeda, T., Narumiya, S., Yasuda, T., Higashi, H., Kitagawa, M., Nakayama, K., Saito, Y., Hirai, A. J. Biol. Chem. (1998)
- Expression of cell cycle regulatory factors in differentiating osteoblasts: postproliferative up-regulation of cyclins B and E. Smith, E., Frenkel, B., Schlegel, R., Giordano, A., Lian, J.B., Stein, J.L., Stein, G.S. Cancer Res. (1995)
- Characterization of Cdk2-cyclin E complexes in plasma membrane and endosomes of liver parenchyma. Insulin-dependent regulation. Gaulin, J.F., Fiset, A., Fortier, S., Faure, R.L. J. Biol. Chem. (2000)
- Expression of G1 Cell Cycle Regulators in Rat Liver upon Repeated Exposure to Thioacetamide. Kim, K.T., Han, S.Y., Jeong, J.S. The Korean journal of hepatology (2007)
- Inhibition of G1 cyclin expression in normal rat kidney cells by inostamycin, a phosphatidylinositol synthesis inhibitor. Deguchi, A., Imoto, M., Umezawa, K. J. Biochem. (1996)
- Nitric oxide-induced downregulation of Cdk2 activity and cyclin A gene transcription in vascular smooth muscle cells. Guo, K., Andrés, V., Walsh, K. Circulation (1998)
- Myc activation of cyclin E/Cdk2 kinase involves induction of cyclin E gene transcription and inhibition of p27(Kip1) binding to newly formed complexes. Pérez-Roger, I., Solomon, D.L., Sewing, A., Land, H. Oncogene (1997)
- G1-arrested FaO cells re-enter the cell cycle upon stimulation with the rodent non-genotoxic hepatocarcinogen nafenopin. Chevalier, S., Roberts, R.A. Carcinogenesis (1999)
- Deregulated expression of E2F-1 induces cyclin A- and E-associated kinase activities independently from cell cycle position. Soucek, T., Pusch, O., Hengstschläger-Ottnad, E., Adams, P.D., Hengstschläger, M. Oncogene (1997)
- Lipoxin A4 inhibits TNF-alpha-induced production of interleukins and proliferation of rat mesangial cells. Wu, S.H., Lu, C., Dong, L., Zhou, G.P., He, Z.G., Chen, Z.Q. Kidney Int. (2005)
- Activation of Cdk2-pRB-E2F1 cell cycle pathway by repeated electroconvulsive shock in the rat frontal cortex. Kim, Y., Seo, M.S., Kang, U.G., Yoon, S.C., Ahn, Y.M., Kim, Y.S., Juhnn, Y.S. Biol. Psychiatry (2005)
- Cyclin D1 is up-regulated in hepatocytes in vivo following cell-cycle block induced by retrorsine. Pitzalis, S., Doratiotto, S., Greco, M., Montisci, S., Pasciu, D., Porcu, G., Pani, P., Laconi, S., Laconi, E. J. Hepatol. (2005)
- Expression of angiotensin type II receptor downregulates Cdk4 synthesis and inhibits cell-cycle progression. Gingras, B., Rodier, G., Giasson, E., Coulombe, P., Chassagne, C., Meloche, S. Oncogene (2003)
- p38 mitogen-activated protein kinase contributes to cell cycle regulation by cAMP in FRTL-5 thyroid cells. Corrèze, C., Blondeau, J.P., Pomérance, M. Eur. J. Endocrinol. (2005)
- After portal branch ligation in the rat, cellular proliferation is associated with selective induction of c-Ha-ras, p53, cyclin E, and Cdk2. Stärkel, P., Lambotte, L., Sempoux, C., De Saeger, C., Saliez, A., Maiter, D., Horsmans, Y. Gut (2001)
- Retinoic acid-induced proliferation of lung alveolar epithelial cells is linked to p21(CIP1) downregulation. Nabeyrat, E., Corroyer, S., Epaud, R., Besnard, V., Cazals, V., Clement, A. Am. J. Physiol. Lung Cell Mol. Physiol. (2000)
- Increased expression of cyclin D1, cyclin E and p21(Cip1) associated with decreased expression of p27(Kip1) in chemically induced rat mammary carcinogenesis. Jang, T.J., Kang, M.S., Kim, H., Kim, D.H., Lee, J.I., Kim, J.R. Jpn. J. Cancer Res. (2000)