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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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TAP1  -  transporter 1, ATP-binding cassette, sub...

Gallus gallus

 
 
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High impact information on TAP1

  • Most of the protein sequence features involved in binding ATP are conserved, with two exceptions: chicken TAP1 has a glycine in the switch region where other TAPs have glutamine or histidine, and both chicken TAP genes have serines in the C motif where mammalian TAP2 has an alanine [1].
  • The truncation of TAP1 results in the loss of approximately 150 amino acids, which are thought to be involved in endoplasmic reticulum retention, heterodimer formation and tapasin binding, compared to human TAP1 [1].
  • Isolation of transporter associated with antigen processing genes, TAP1 and TAP2, from the horned shark Heterodontus francisci [2].
  • Experiments performed with BMs from transporter associated with antigen processing (TAP1) knock-out mice demonstrated that the translocation of peptides into the trans-Golgi area was dependent upon TAP1 protein [3].

References

  1. Chicken TAP genes differ from their human orthologues in locus organisation, size, sequence features and polymorphism. Walker, B.A., van Hateren, A., Milne, S., Beck, S., Kaufman, J. Immunogenetics (2005) [Pubmed]
  2. Isolation of transporter associated with antigen processing genes, TAP1 and TAP2, from the horned shark Heterodontus francisci. Ohta, Y., Haliniewski, D.E., Hansen, J., Flajnik, M.F. Immunogenetics (1999) [Pubmed]
  3. Visualization of peptides derived from liposome-encapsulated proteins in the trans-Golgi area of macrophages. Rao, M., Rothwell, S.W., Wassef, N.M., Pagano, R.E., Alving, C.R. Immunol. Lett. (1997) [Pubmed]
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