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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SKI  -  v-ski avian sarcoma viral oncogene homolog

Gallus gallus

 
 
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Disease relevance of SKI

  • Quail embryo cells, induced to differentiate along the myogenic pathway by infection with avian SKV retroviruses expressing the ski oncogene, were microinjected with affinity purified anti-D26 at the mononucleated, myoblast stage [1].
 

High impact information on SKI

  • C-ski transcripts with and without exon 2 are expressed in skeletal muscle and throughout chick embryogenesis [2].
  • C-ski cDNAs are encoded by eight exons, six of which are closely linked within the chicken genome [3].
  • The ski oncogene encodes a transcription factor that induces both transformation and muscle differentiation in avian fibroblasts [4].
  • No differences in AC activity were found for the F2 follicles whether they were C1, C2, CT or Cskip [5].
  • F1 and F2 follicles removed on C1, C2, CT, and Cskip had been these specific follicles for 32 h, 12 h, 10 h, and 8 h, respectively [5].
 

Biological context of SKI

  • F1 and F2 follicles were obtained at lights off on nights before the first (C1; n = 7), second (C2; n = 7), or terminal ovulation (CT; n = 5) or the night before the day when no ovulation was expected (Cskip; n = 6) [5].

References

  1. Site-specific antibodies block kinase A phosphorylation of desmin in vitro and inhibit incorporation of myoblasts into myotubes. Tao, J.X., Ip, W. Cell Motil. Cytoskeleton (1991) [Pubmed]
  2. C-ski transcripts with and without exon 2 are expressed in skeletal muscle and throughout chick embryogenesis. Grimes, H.L., Ambrose, M.R., Goodenow, M.M. Oncogene (1993) [Pubmed]
  3. C-ski cDNAs are encoded by eight exons, six of which are closely linked within the chicken genome. Grimes, H.L., Szente, B.E., Goodenow, M.M. Nucleic Acids Res. (1992) [Pubmed]
  4. Association of specific DNA binding and transcriptional repression with the transforming and myogenic activities of c-Ski. Nicol, R., Zheng, G., Sutrave, P., Foster, D.N., Stavnezer, E. Cell Growth Differ. (1999) [Pubmed]
  5. Relative luteinizing hormone-stimulable adenylyl cyclase of the preovulatory follicle: a predictor of ovulation in the domestic hen. Johnson, P.A., Bahr, J.M. Biol. Reprod. (1985) [Pubmed]
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