High impact information on SKI

• These results indicate that HIPK2, together with c-Ski, plays an important role in the negative regulation of BMP-induced transcriptional activation [1].
• Furthermore, the c-Ski-induced inhibition of the Smad1/4-dependent transcription was suppressed by a dominant negative form of HIPK2 [1].
• Thus, Ski and SnoN have the capacity to associate with other proteins, and a complex formation of c-Ski with itself, SnoN, and uncharacterized proteins might play a key role in the function of Ski [2].
• The c-ski proto-oncogene product (c-Ski) is localized in the nuclei, but its function and biochemical properties are unclear [2].
• Finally, the calcyclin gene has been localized to the long arm of human chromosome 1, near the ski oncogene [3].

Biological context of SKI

• The ski oncogene is the transforming gene, v-ski, of the defective SKV avian carcinoma viruses [4].
• Although the ski oncogene plays a role in cell proliferation, morphological transformation, and myogenic differentiation, the myogenic activities of the proto-oncogene c-ski have yet to be elucidated. c-ski is expressed within myoblasts during embryogenesis [5].

Anatomical context of SKI

• sno is a member of the ski oncogene family and shares ski 's ability to transform avian fibroblasts and induce muscle differentiation [6].

Regulatory relationships of SKI

• C-ski is a complicated regulating factor for fibroblast proliferation and an important co-repressor of Smad3 [7].

References