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Gene Review

MC1R  -  melanocortin 1 receptor (alpha melanocyte...

Gallus gallus

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Disease relevance of MC1R

  • The conserved molecular basis for the evolution of melanism in birds and several other vertebrates is probably related to low pleiotropic effects at the MC1R [1].

High impact information on MC1R


Biological context of MC1R


Physical interactions of MC1R

  • Most of those AGRP-expressing tissues have been demonstrated to express melanocortin 4 receptors and/or other subtypes of melanocortin receptor whose mammalian counterparts can bind AGRP [8].

Other interactions of MC1R

  • This article reviews our work on MC1R variants in horse, pig, and chicken, as well as a study on MC4R polymorphism in the pig [6].
  • Interestingly, the skin also expressed the AGRP mRNA, where Agouti, another melanocortin receptor antagonist regulating hair pigmentation, is expressed in rodents [8].


  1. A window on the genetics of evolution: MC1R and plumage colouration in birds. Mundy, N.I. Proc. Biol. Sci. (2005) [Pubmed]
  2. The molecular basis of an avian plumage polymorphism in the wild: a melanocortin-1-receptor point mutation is perfectly associated with the melanic plumage morph of the bananaquit, Coereba flaveola. Theron, E., Hawkins, K., Bermingham, E., Ricklefs, R.E., Mundy, N.I. Curr. Biol. (2001) [Pubmed]
  3. FAS inhibitor cerulenin reduces food intake and melanocortin receptor gene expression without modulating the other (an)orexigenic neuropeptides in chickens. Dridi, S., Ververken, C., Hillgartner, F.B., Arckens, L., Lutgarde, A., Van der Gucht, E., Cnops, L., Decuypere, E., Buyse, J. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2006) [Pubmed]
  4. Identification of avian alpha-melanocyte-stimulating hormone in the eye: temporal and spatial regulation of expression in the developing chicken. Teshigawara, K., Takahashi, S., Boswell, T., Li, Q., Tanaka, S., Takeuchi, S. J. Endocrinol. (2001) [Pubmed]
  5. Melanocortin 1-receptor (MC1R) mutations are associated with plumage colour in chicken. Kerje, S., Lind, J., Schütz, K., Jensen, P., Andersson, L. Anim. Genet. (2003) [Pubmed]
  6. Melanocortin receptor variants with phenotypic effects in horse, pig, and chicken. Andersson, L. Ann. N. Y. Acad. Sci. (2003) [Pubmed]
  7. Assignment of fourteen microsatellite markers to the chicken linkage map. Jacobsson, L., Park, H.B., Wahlberg, P., Jiang, S., Siegel, P.B., Andersson, L. Poult. Sci. (2004) [Pubmed]
  8. Widespread expression of Agouti-related protein (AGRP) in the chicken: a possible involvement of AGRP in regulating peripheral melanocortin systems in the chicken. Takeuchi, S., Teshigawara, K., Takahashi, S. Biochim. Biophys. Acta (2000) [Pubmed]
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