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Gene Review

cav  -  caravaggio

Drosophila melanogaster

Synonyms: 1G5, Anon1G5, Anonymous fast evolving 1G5, CG6219, Caravaggio, ...
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High impact information on cav

  • Here, we show that caravaggio, a mutation in the HOAP-encoding gene, causes extensive telomere-telomere fusions in larval brain cells, indicating that HOAP is required for telomere capping [1].
  • This suggests that the MRN complex protects Drosophila telomeres by facilitating recruitment of HOAP and HP1 at chromosome ends [2].
  • Mutations designed to mimic hyper-phosphorylation render the protein incapable of binding HOAP and the DmORC1 subunit but confer enhanced homo-dimerization and lysine 9-methylated histone H3-binding to the protein [3].

Biological context of cav


Other interactions of cav


  1. The Drosophila HOAP protein is required for telomere capping. Cenci, G., Siriaco, G., Raffa, G.D., Kellum, R., Gatti, M. Nat. Cell Biol. (2003) [Pubmed]
  2. The Drosophila Mre11/Rad50 complex is required to prevent both telomeric fusion and chromosome breakage. Ciapponi, L., Cenci, G., Ducau, J., Flores, C., Johnson-Schlitz, D., Gorski, M.M., Engels, W.R., Gatti, M. Curr. Biol. (2004) [Pubmed]
  3. Mutations in the heterochromatin protein 1 (HP1) hinge domain affect HP1 protein interactions and chromosomal distribution. Badugu, R., Yoo, Y., Singh, P.B., Kellum, R. Chromosoma (2005) [Pubmed]
  4. Novel Drosophila heterochromatin protein 1 (HP1)/origin recognition complex-associated protein (HOAP) repeat motif in HP1/HOAP interactions and chromocenter associations. Badugu, R., Shareef, M.M., Kellum, R. J. Biol. Chem. (2003) [Pubmed]
  5. Epigenetic telomere protection by Drosophila DNA damage response pathways. Oikemus, S.R., Queiroz-Machado, J., Lai, K., McGinnis, N., Sunkel, C., Brodsky, M.H. PLoS Genet. (2006) [Pubmed]
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