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Gene Review

MDD2  -  Major depressive disorder 2

Homo sapiens

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Disease relevance of MDD2


High impact information on MDD2

  • Azurin, a copper-containing redox protein released by the pathogenic bacterium Pseudomonas aeruginosa, is highly cytotoxic to the human breast cancer cell line MCF-7, but is less cytotoxic toward p53-negative (MDA-MB-157) or nonfunctional p53 cell lines like MDD2 and MDA-MB-231 [3].
  • The human breast carcinoma cell line MCF7 and its derivatives, MCF7/HER-2 and MDD2, were used in the study [4].
  • The MDD2 cell line was significantly more resistant to the cytotoxic effects of vinblastine and paclitaxel than the MN1 cell line [2].
  • Addition of flavopiridol to vinblastine- and paclitaxel-treated cells reversed the MDD2-resistant phenotype by inducing G(1)cell cycle arrest and inhibiting endoreduplication [2].
  • After exposure to vinblastine, Raf 1 kinase activity was reduced in MDD2 cells but not in MN1 cells [2].

Other interactions of MDD2


  1. Labd-14-ene-8,13-diol (sclareol) induces cell cycle arrest and apoptosis in human breast cancer cells and enhances the activity of anticancer drugs. Dimas, K., Papadaki, M., Tsimplouli, C., Hatziantoniou, S., Alevizopoulos, K., Pantazis, P., Demetzos, C. Biomed. Pharmacother. (2006) [Pubmed]
  2. Inactivation of wild-type p53 by a dominant negative mutant renders MCF-7 cells resistant to tubulin-binding agent cytotoxicity. Galmarini, C.M., Falette, N., Tabone, E., Levrat, C., Britten, R., Voorzanger-Rousselot, N., Roesch-Gateau, O., Vanier-Viornery, A., Puisieux, A., Dumontet, C. Br. J. Cancer (2001) [Pubmed]
  3. Bacterial cupredoxin azurin as an inducer of apoptosis and regression in human breast cancer. Punj, V., Bhattacharyya, S., Saint-Dic, D., Vasu, C., Cunningham, E.A., Graves, J., Yamada, T., Constantinou, A.I., Christov, K., White, B., Li, G., Majumdar, D., Chakrabarty, A.M., Das Gupta, T.K. Oncogene (2004) [Pubmed]
  4. Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53. Bacus, S.S., Gudkov, A.V., Lowe, M., Lyass, L., Yung, Y., Komarov, A.P., Keyomarsi, K., Yarden, Y., Seger, R. Oncogene (2001) [Pubmed]
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