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Gene Review:

btz - barentsz

Drosophila melanogaster

Synonyms: Btz, CG12878, Dmel\CG12878, wkl

van Eeden, F.J. et al., Palacios, I.M. et al., Macchi, P. et al., Wilhelm, J.E. et al.

Wilhelm, Hilton, Amos, Henzel,

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High impact information on btz

Cup is an eIF4E binding protein required for both the translational repression of oskar and the recruitment of Barentsz [1].
Although Barentsz localization in the germ line depends on Mago-Y14, no direct interaction between these proteins has been detected [2].
When expressed in the Drosophila egg chamber, mammalian Btz is still able to interact with Drosophila Staufen and reach the posterior pole in the wild-type oocyte, but does not rescue the btz mutant phenotype [3].

Biological context of btz

Thus, Barentsz is essential for the posterior localization of oskar mRNA and behaves as a specific component of the oskar RNA transport complex [4].

Co-localisations of btz

Barentsz protein colocalizes to the posterior with oskar mRNA, and this localization is oskar mRNA dependent [4].

Other interactions of btz

Barentsz is essential for the posterior localization of oskar mRNA and colocalizes with it to the posterior pole [4].

References

Cup is an eIF4E binding protein required for both the translational repression of oskar and the recruitment of Barentsz. Wilhelm, J.E., Hilton, M., Amos, Q., Henzel, W.J. J. Cell Biol. (2003) [Pubmed]
An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay. Palacios, I.M., Gatfield, D., St Johnston, D., Izaurralde, E. Nature (2004) [Pubmed]
Barentsz, a new component of the Staufen-containing ribonucleoprotein particles in mammalian cells, interacts with Staufen in an RNA-dependent manner. Macchi, P., Kroening, S., Palacios, I.M., Baldassa, S., Grunewald, B., Ambrosino, C., Goetze, B., Lupas, A., St Johnston, D., Kiebler, M. J. Neurosci. (2003) [Pubmed]
Barentsz is essential for the posterior localization of oskar mRNA and colocalizes with it to the posterior pole. van Eeden, F.J., Palacios, I.M., Petronczki, M., Weston, M.J., St Johnston, D. J. Cell Biol. (2001) [Pubmed]

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