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Gene Review

Cad99C  -  Cadherin 99C

Drosophila melanogaster

Synonyms: CA-10, CG15511, CG310034, CG31009, CG7805, ...
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High impact information on Cad99C

  • Loss of Cad99C function results in shortened and disorganized microvilli, whereas overexpression of Cad99C leads to a dramatic increase of microvillus length [1].
  • Our data suggest an essential role for Cad99C in microvilli morphogenesis that is important for follicle cell function [2].
  • Cad99C encodes a transmembrane protein with a molecular weight of approximately 184 kDa that contains 11 cadherin repeats in its extracellular domain and a conserved type I PDZ-binding site at its C-terminus [3].
  • Here, we molecularly characterize the previously predicted gene cad99C and show that it is regulated by Hedgehog signaling [3].

Anatomical context of Cad99C


Analytical, diagnostic and therapeutic context of Cad99C

  • Finally, by analyzing mutant clones of cells, we show that Cad99C is not essential for cell segregation at the A/P boundary [3].


  1. Drosophila melanogaster Cad99C, the orthologue of human Usher cadherin PCDH15, regulates the length of microvilli. D'Alterio, C., Tran, D.D., Yeung, M.W., Hwang, M.S., Li, M.A., Arana, C.J., Mulligan, V.K., Kubesh, M., Sharma, P., Chase, M., Tepass, U., Godt, D. J. Cell Biol. (2005) [Pubmed]
  2. Cadherin Cad99C is required for normal microvilli morphology in Drosophila follicle cells. Schlichting, K., Wilsch-Bräuninger, M., Demontis, F., Dahmann, C. J. Cell. Sci. (2006) [Pubmed]
  3. Cadherin Cad99C is regulated by Hedgehog signaling in Drosophila. Schlichting, K., Demontis, F., Dahmann, C. Dev. Biol. (2005) [Pubmed]
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