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Gene Review:

Anp - Andropin

Drosophila melanogaster

Synonyms: ANR, And, CEC, CG1361, Cec, ...

Zhou, X. et al., Date-Ito, A. et al., Clark, A.G. et al.

Date-Ito, Kasahara, Sawai, Chigusa,

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High impact information on Anp

Andropin, which encodes an antibacterial protein, is closely linked to the Cecropin gene cluster of D. melanogaster [1].
However, the expression pattern of Andropin is distinct from that of Cecropins, being restricted to the adult male ejaculatory duct [1].
Estimates of variation levels show that the genes are not exceptionally polymorphic, but Andropin and Diptericin have patterns of variation that differ significantly from neutrality [2].
An Andropin-related sequence was not identified in D. virilis; however, genome Southern hybridizations suggest that Andropin-related sequences are present in at least the melanogaster species subgroup [3].
As a first step in studying the molecular evolution of the cecropin and andropin genes among Drosophila species, we have isolated genomic clones that cover the Cecropin locus in Drosophila virilis [3].

References

Rapid evolution of the male-specific antibacterial protein andropin gene in Drosophila. Date-Ito, A., Kasahara, K., Sawai, H., Chigusa, S.I. J. Mol. Evol. (2002) [Pubmed]
Molecular population genetics of Drosophila immune system genes. Clark, A.G., Wang, L. Genetics (1997) [Pubmed]
Identification and characterization of the Cecropin antibacterial protein gene locus in Drosophila virilis. Zhou, X., Nguyen, T., Kimbrell, D.A. J. Mol. Evol. (1997) [Pubmed]

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