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Gene Review

Dpt  -  Diptericin

Drosophila melanogaster

Synonyms: 143443_at, CG12763, DIPT, DPT, Dep, ...
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Disease relevance of Dpt


High impact information on Dpt

  • NO induction of Diptericin reporters in the fat body required immune deficiency (imd) and domino [1].
  • To dissect the regulation of this gene, we have transformed flies with a fusion gene in which the reporter beta-galactosidase gene is under the control of 2.2 kb upstream sequences of the diptericin gene [4].
  • Conversely, ectopic expression of caspar strongly suppressed the infection-dependent gene expression of diptericin, which allowed bacterial outgrowth [2].
  • The DLAK(K50A) mutant also inhibits nuclear kappaB binding activity and kappaB-dependent diptericin reporter gene activity in a dose-dependent manner, but the kappaB-dependent diptericin reporter gene activity can be rescued by overexpression of wild type DLAK [5].
  • Furthermore, we found that ectopic expression of Nef inhibits Drosophila innate immune responses including Relish NF-kappaB activation with subsequent induction of an antimicrobial peptide, diptericin [6].

Biological context of Dpt

  • We show that such a fusion gene is inducible by injection of live bacteria or complete Freund's adjuvant and respects the tissue specific expression pattern of the resident diptericin gene [4].
  • The upstream sequences of the diptericin and cecropin Al genes, which have been investigated in detail, contain two, respectively one sequence element homologous to the binding site of the mammalian nuclear factor kappaB [7].
  • Specific assays for Dip A and Dip B were used to show that for each of these isozymes, the activity in an adult is proportional to gene dosage [8].

Other interactions of Dpt

  • Estimates of variation levels show that the genes are not exceptionally polymorphic, but Andropin and Diptericin have patterns of variation that differ significantly from neutrality [9].


  1. Nitric oxide contributes to induction of innate immune responses to gram-negative bacteria in Drosophila. Foley, E., O'Farrell, P.H. Genes Dev. (2003) [Pubmed]
  2. Caspar, a suppressor of antibacterial immunity in Drosophila. Kim, M., Lee, J.H., Lee, S.Y., Kim, E., Chung, J. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  3. Prevalence of local immune response against oral infection in a Drosophila/Pseudomonas infection model. Liehl, P., Blight, M., Vodovar, N., Boccard, F., Lemaitre, B. PLoS Pathog. (2006) [Pubmed]
  4. Insect immunity: developmental and inducible activity of the Drosophila diptericin promoter. Reichhart, J.M., Meister, M., Dimarcq, J.L., Zachary, D., Hoffmann, D., Ruiz, C., Richards, G., Hoffmann, J.A. EMBO J. (1992) [Pubmed]
  5. Lipopolysaccharide-activated kinase, an essential component for the induction of the antimicrobial peptide genes in Drosophila melanogaster cells. Kim, Y.S., Han, S.J., Ryu, J.H., Choi, K.H., Hong, Y.S., Chung, Y.H., Perrot, S., Raibaud, A., Brey, P.T., Lee, W.J. J. Biol. Chem. (2000) [Pubmed]
  6. Nef induces apoptosis by activating JNK signaling pathway and inhibits NF-kappaB-dependent immune responses in Drosophila. Lee, S.B., Park, J., Jung, J.U., Chung, J. J. Cell. Sci. (2005) [Pubmed]
  7. Drosophila immunity: a comparative analysis of the Rel proteins dorsal and Dif in the induction of the genes encoding diptericin and cecropin. Gross, I., Georgel, P., Kappler, C., Reichhart, J.M., Hoffmann, J.A. Nucleic Acids Res. (1996) [Pubmed]
  8. Peptidases in Drosophila melanogaster. I. Characterization of dipeptidase and leucine aminopeptidase activities. Hall, N.A. Biochem. Genet. (1986) [Pubmed]
  9. Molecular population genetics of Drosophila immune system genes. Clark, A.G., Wang, L. Genetics (1997) [Pubmed]
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