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Gene Review

pygo  -  pygopus

Drosophila melanogaster

Synonyms: BEST:LD21971, CG11518, Dm Pygo, Dmel\CG11518, Protein gammy legs, ...
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Disease relevance of pygo

  • Humans possess two Pygo proteins, both of which are required for TCF-mediated transcription in colorectal cancer cells [1].

High impact information on pygo

  • Pygopus and Legless target Armadillo/beta-catenin to the nucleus to enable its transcriptional co-activator function [2].
  • Here, we show that the nuclear localization of Lgs entirely depends on Pygo, which itself is constitutively localized to the nucleus; thus, Pygo functions as a nuclear anchor [2].
  • We show that Wg signaling is diminished during embryogenesis and imaginal disc development in the absence of pygo activity [3].
  • We further show that Pygo can form a complex with Arm in vivo and possesses a transcription activation domain(s) [3].
  • The pygopus mutant phenotype is highly, though not exclusively, specific for Wg signaling [4].

Biological context of pygo


Anatomical context of pygo

  • Here, we report that Pygo is associated constitutively with dTCF target genes in Drosophila salivary glands and tissue-culture cells [5].
  • Here, we analyse the mode of action of Pan, Arm, Lgs, and Pygo in Drosophila cultured cells [6].

Associations of pygo with chemical compounds

  • Wingless-Independent Association of Pygopus with dTCF Target Genes [5].
  • We provide evidence that together these four proteins form a 'chain of adaptors' linking the NH2-terminal homology domain (NHD) of Pygo to the DNA-binding domain of Pan. We show that the NHD has potent transcriptional activation capacity, which differs from that of acidic activator domains and depends on a conserved NPF tripeptide [6].


  1. A new nuclear component of the Wnt signalling pathway. Thompson, B., Townsley, F., Rosin-Arbesfeld, R., Musisi, H., Bienz, M. Nat. Cell Biol. (2002) [Pubmed]
  2. Pygopus and Legless target Armadillo/beta-catenin to the nucleus to enable its transcriptional co-activator function. Townsley, F.M., Cliffe, A., Bienz, M. Nat. Cell Biol. (2004) [Pubmed]
  3. pygopus Encodes a nuclear protein essential for wingless/Wnt signaling. Belenkaya, T.Y., Han, C., Standley, H.J., Lin, X., Houston, D.W., Heasman, J., Lin, X. Development (2002) [Pubmed]
  4. Pygopus, a nuclear PHD-finger protein required for Wingless signaling in Drosophila. Parker, D.S., Jemison, J., Cadigan, K.M. Development (2002) [Pubmed]
  5. Wingless-Independent Association of Pygopus with dTCF Target Genes. de la Roche, M., Bienz, M. Curr. Biol. (2007) [Pubmed]
  6. Dissecting nuclear Wingless signalling: recruitment of the transcriptional co-activator Pygopus by a chain of adaptor proteins. Städeli, R., Basler, K. Mech. Dev. (2005) [Pubmed]
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