The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Flexfree     2-(4-phenylphenyl)ethanoic acid

Synonyms: Ledergel, Napageln, Seltouch, felbinac, Dolinac, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Napageln


Psychiatry related information on Napageln


High impact information on Napageln


Chemical compound and disease context of Napageln


Biological context of Napageln


Anatomical context of Napageln


Associations of Napageln with other chemical compounds


Gene context of Napageln


Analytical, diagnostic and therapeutic context of Napageln

  • Standards for supervised cardiovascular exercise maintenance programs. Report of the Subcommittee on Exercise/Rehabilitation, Target Activity Group [41].
  • RESULTS: Early reperfusion was associated with significantly increased odds of achieving a favorable clinical response in patients with a perfusion/diffusion mismatch (odds ratio, 5.4; p = 0.039) and an even more favorable response in patients with the Target Mismatch profile (odds ratio, 8.7; p = 0.011) [42].
  • Pathogenesis of DNA repair-deficient cancers: a statistical meta-analysis of putative Real Common Target genes [43].
  • Using a structured modelling analysis, the YBOCS and the CC were compared with a latent factor derived from five other variables (Target Rituals, Target Obsession, Clinical Global Impression, Avoidance, Disability) of baseline severity and change after treatment, and also directly with those variables [44].
  • CONCLUSION: Target organ-specific interventions that suppress antigen presentation may have an adjunctive role in transplantation tolerance [45].


  1. GP120: Target for Neutralizing HIV-1 Antibodies. Pantophlet, R., Burton, D.R. Annu. Rev. Immunol. (2006) [Pubmed]
  2. Retraction. Target platelet antigen in homosexual men with immune thrombocytopenia. Shuman, M.A., Corash, L., Abrams, D.I., Hittelman, K.J. N. Engl. J. Med. (1991) [Pubmed]
  3. mTOR Pathway as a Target in Tissue Hypertrophy. Lee, C.H., Inoki, K., Guan, K.L. Annu. Rev. Pharmacol. Toxicol. (2007) [Pubmed]
  4. Cardiac and arterial target organ damage in adults with elevated ambulatory and normal office blood pressure. Liu, J.E., Roman, M.J., Pini, R., Schwartz, J.E., Pickering, T.G., Devereux, R.B. Ann. Intern. Med. (1999) [Pubmed]
  5. Nitric Oxide in Physiologic Concentrations Targets the Translational Machinery to Increase the Proliferation of Human Breast Cancer Cells: Involvement of Mammalian Target of Rapamycin/eIF4E Pathway. Pervin, S., Singh, R., Hernandez, E., Wu, G., Chaudhuri, G. Cancer Res. (2007) [Pubmed]
  6. Comparison of injectable molindone and haloperidol followed by oral dosage forms in acutely ill schizophrenics. Escobar, J.I., Mann, J.J., Keller, J., Wilkins, J., Mason, B., Mills, M.J. The Journal of clinical psychiatry. (1985) [Pubmed]
  7. An open trial of valproate in borderline personality disorder. Stein, D.J., Simeon, D., Frenkel, M., Islam, M.N., Hollander, E. The Journal of clinical psychiatry. (1995) [Pubmed]
  8. Psychotherapeutic outcome: measuring reliable clinical change. Dormaar, M., Dijkman, C.I., deVries, M.W. Psychotherapy and psychosomatics. (1988) [Pubmed]
  9. Separate and shared sources of dual-task cost in stimulus identification and response selection. Arnell, K.M., Duncan, J. Cognitive psychology. (2002) [Pubmed]
  10. The combination of 2% 4-hydroxyanisole (Mequinol) and 0.01% tretinoin is effective in improving the appearance of solar lentigines and related hyperpigmented lesions in two double-blind multicenter clinical studies. Fleischer, A.B., Schwartzel, E.H., Colby, S.I., Altman, D.J. J. Am. Acad. Dermatol. (2000) [Pubmed]
  11. 4E-BP functions as a metabolic brake used under stress conditions but not during normal growth. Teleman, A.A., Chen, Y.W., Cohen, S.M. Genes Dev. (2005) [Pubmed]
  12. Murine syngeneic mixed lymphocyte response. I. Target antigens are self Ia molecules. Glimcher, L.H., Longo, D.L., Green, I., Schwartz, R.H. J. Exp. Med. (1981) [Pubmed]
  13. Suppressor-cell induction in vitro. IV. Target of antigen-specific suppressor factor and its genetic relationships. Kontiainen, S., Feldmann, M. J. Exp. Med. (1978) [Pubmed]
  14. Cell-Intrinsic Regulation of Axonal Morphogenesis by the Cdh1-APC Target SnoN. Stegmüller, J., Konishi, Y., Huynh, M.A., Yuan, Z., Dibacco, S., Bonni, A. Neuron (2006) [Pubmed]
  15. Mechanism of metabolic control. Target of rapamycin signaling links nitrogen quality to the activity of the Rtg1 and Rtg3 transcription factors. Komeili, A., Wedaman, K.P., O'Shea, E.K., Powers, T. J. Cell Biol. (2000) [Pubmed]
  16. Combination Mammalian Target of Rapamycin Inhibitor Rapamycin and HSP90 Inhibitor 17-Allylamino-17-Demethoxygeldanamycin Has Synergistic Activity in Multiple Myeloma. Francis, L.K., Alsayed, Y., Leleu, X., Jia, X., Singha, U.K., Anderson, J., Timm, M., Ngo, H., Lu, G., Huston, A., Ehrlich, L.A., Dimmock, E., Lentzsch, S., Hideshima, T., Roodman, G.D., Anderson, K.C., Ghobrial, I.M. Clin. Cancer Res. (2006) [Pubmed]
  17. STATT: a titrate-to-goal study of simvastatin in Asian patients with coronary heart disease. Simvastatin Treats Asians to Target. Chung, N., Cho, S.Y., Choi, D.H., Zhu, J.R., Lee, K., Lee, P.Y., Lee, S.H., Lee, S., Wang, J.J., Yin, W.H., Young, M.S., Koh, K.K., Son, J.W., Sangwatanaroj, S., Panchavinnin, P., Phankingthongkum, R., Cai, N.S., Fan, W.F. Clinical therapeutics. (2001) [Pubmed]
  18. Lack of potentiation with felbinac patch on the convulsive toxicity of enoxacin in rats. Ohtani, H., Noma, S., Kawakami, J., Sawada, Y., Iga, T. Biol. Pharm. Bull. (1996) [Pubmed]
  19. National service framework for coronary heart disease. Target of lowering cholesterol by 30% needs to be justified. Cracknell, P. BMJ (2000) [Pubmed]
  20. Transcriptome Analysis of Temporal Regulation of Carbon Metabolism by CcpA in Bacillus subtilis Reveals Additional Target Genes. Lulko, A.T., Buist, G., Kok, J., Kuipers, O.P. J. Mol. Microbiol. Biotechnol. (2007) [Pubmed]
  21. The embryo MADS domain protein AGAMOUS-Like 15 directly regulates expression of a gene encoding an enzyme involved in gibberellin metabolism. Wang, H., Caruso, L.V., Downie, A.B., Perry, S.E. Plant Cell (2004) [Pubmed]
  22. The Microphthalmia-Associated Transcription Factor Mitf Interacts with {beta}-Catenin To Determine Target Gene Expression. Schepsky, A., Bruser, K., Gunnarsson, G.J., Goodall, J., Hallsson, J.H., Goding, C.R., Steingrimsson, E., Hecht, A. Mol. Cell. Biol. (2006) [Pubmed]
  23. Inhibition of Mammalian Target of Rapamycin or Apoptotic Pathway Induces Autophagy and Radiosensitizes PTEN Null Prostate Cancer Cells. Cao, C., Subhawong, T., Albert, J.M., Kim, K.W., Geng, L., Sekhar, K.R., Gi, Y.J., Lu, B. Cancer Res. (2006) [Pubmed]
  24. High-versus standard-dose filgrastim (rhG-CSF) for mobilization of peripheral-blood progenitor cells from allogeneic donors and CD34(+) immunoselection. Engelhardt, M., Bertz, H., Afting, M., Waller, C.F., Finke, J. J. Clin. Oncol. (1999) [Pubmed]
  25. Drosophila Paired regulates late even-skipped expression through a composite binding site for the paired domain and the homeodomain. Fujioka, M., Miskiewicz, P., Raj, L., Gulledge, A.A., Weir, M., Goto, T. Development (1996) [Pubmed]
  26. Patterns of calcification in coronary artery disease. A statistical analysis of intravascular ultrasound and coronary angiography in 1155 lesions. Mintz, G.S., Popma, J.J., Pichard, A.D., Kent, K.M., Satler, L.F., Chuang, Y.C., Ditrano, C.J., Leon, M.B. Circulation (1995) [Pubmed]
  27. HBXIP, Cellular Target of Hepatitis B Virus Oncoprotein, Is a Regulator of Centrosome Dynamics and Cytokinesis. Fujii, R., Zhu, C., Wen, Y., Marusawa, H., Bailly-Maitre, B., Matsuzawa, S., Zhang, H., Kim, Y., Bennett, C.F., Jiang, W., Reed, J.C. Cancer Res. (2006) [Pubmed]
  28. Targeting the AIB1 Oncogene through Mammalian Target of Rapamycin Inhibition in the Mammary Gland. Torres-Arzayus, M.I., Yuan, J., Dellagatta, J.L., Lane, H., Kung, A.L., Brown, M. Cancer Res. (2006) [Pubmed]
  29. A Role for Mammalian Target of Rapamycin in Regulating T Cell Activation versus Anergy. Zheng, Y., Collins, S.L., Lutz, M.A., Allen, A.N., Kole, T.P., Zarek, P.E., Powell, J.D. J. Immunol. (2007) [Pubmed]
  30. 3D7-Derived Plasmodium falciparum Erythrocyte Membrane Protein 1 Is a Frequent Target of Naturally Acquired Antibodies Recognizing Protein Domains in a Particular Pattern Independent of Malaria Transmission Intensity. Joergensen, L., Vestergaard, L.S., Turner, L., Magistrado, P., Lusingu, J.P., Lemnge, M., Theander, T.G., Jensen, A.T. J. Immunol. (2007) [Pubmed]
  31. Identification of T-cadherin as a Novel Target of DNA Methyltransferase 3B and Its Role in the Suppression of Nerve Growth Factor-mediated Neurite Outgrowth in PC12 Cells. Bai, S., Ghoshal, K., Jacob, S.T. J. Biol. Chem. (2006) [Pubmed]
  32. Mutational Analysis of Encephalitozoon cuniculi mRNA Cap (Guanine-N7) Methyltransferase, Structure of the Enzyme Bound to Sinefungin, and Evidence That Cap Methyltransferase Is the Target of Sinefungin's Antifungal Activity. Zheng, S., Hausmann, S., Liu, Q., Ghosh, A., Schwer, B., Lima, C.D., Shuman, S. J. Biol. Chem. (2006) [Pubmed]
  33. Regulation of Leukocyte Degranulation by cGMP-Dependent Protein Kinase and Phosphoinositide 3-Kinase: Potential Roles in Phosphorylation of Target Membrane SNARE Complex Proteins in Rat Mast Cells. Nanamori, M., Chen, J., Du, X., Ye, R.D. J. Immunol. (2007) [Pubmed]
  34. Dexamethasone Represses Signaling through the Mammalian Target of Rapamycin in Muscle Cells by Enhancing Expression of REDD1. Wang, H., Kubica, N., Ellisen, L.W., Jefferson, L.S., Kimball, S.R. J. Biol. Chem. (2006) [Pubmed]
  35. Insulin-Mediated Phosphorylation of the Proline-Rich Akt Substrate PRAS40 Is Impaired in Insulin Target Tissues of High-Fat Diet-Fed Rats. Nascimento, E.B., Fodor, M., van der Zon, G.C., Jazet, I.M., Meinders, A.E., Voshol, P.J., Vlasblom, R., Baan, B., Eckel, J., Maassen, J.A., Diamant, M., Ouwens, D.M. Diabetes (2006) [Pubmed]
  36. Human CD4+ T Cells Lyse Target Cells via Granzyme/Perforin upon Circumvention of MHC Class II Restriction by an Antibody-Like Immunoreceptor. Hombach, A., K??hler, H., Rappl, G., Abken, H. J. Immunol. (2006) [Pubmed]
  37. Vac1p coordinates Rab and phosphatidylinositol 3-kinase signaling in Vps45p-dependent vesicle docking/fusion at the endosome. Peterson, M.R., Burd, C.G., Emr, S.D. Curr. Biol. (1999) [Pubmed]
  38. The Insulin-like Growth Factor-binding Protein 1 Gene Is a Primary Target of Peroxisome Proliferator-activated Receptors. Degenhardt, T., Matilainen, M., Herzig, K.H., Dunlop, T.W., Carlberg, C. J. Biol. Chem. (2006) [Pubmed]
  39. Expression of HIF-1{alpha}, HIF-2{alpha} (EPAS1), and Their Target Genes in Paraganglioma and Pheochromocytoma with VHL and SDH Mutations. Pollard, P.J., El-Bahrawy, M., Poulsom, R., Elia, G., Killick, P., Kelly, G., Hunt, T., Jeffery, R., Seedhar, P., Barwell, J., Latif, F., Gleeson, M.J., Hodgson, S.V., Stamp, G.W., Tomlinson, I.P., Maher, E.R. J. Clin. Endocrinol. Metab. (2006) [Pubmed]
  40. FGFR1 Emerges as a Potential Therapeutic Target for Lobular Breast Carcinomas. Reis-Filho, J.S., Simpson, P.T., Turner, N.C., Lambros, M.B., Jones, C., Mackay, A., Grigoriadis, A., Sarrio, D., Savage, K., Dexter, T., Iravani, M., Fenwick, K., Weber, B., Hardisson, D., Schmitt, F.C., Palacios, J., Lakhani, S.R., Ashworth, A. Clin. Cancer Res. (2006) [Pubmed]
  41. Standards for supervised cardiovascular exercise maintenance programs. Report of the Subcommittee on Exercise/Rehabilitation, Target Activity Group. Erb, B.D., Fletcher, G.F., Sheffield, L.T. Circulation (1980) [Pubmed]
  42. Magnetic resonance imaging profiles predict clinical response to early reperfusion: The diffusion and perfusion imaging evaluation for understanding stroke evolution (DEFUSE) study. Albers, G.W., Thijs, V.N., Wechsler, L., Kemp, S., Schlaug, G., Skalabrin, E., Bammer, R., Kakuda, W., Lansberg, M.G., Shuaib, A., Coplin, W., Hamilton, S., Moseley, M., Marks, M.P. Ann. Neurol. (2006) [Pubmed]
  43. Pathogenesis of DNA repair-deficient cancers: a statistical meta-analysis of putative Real Common Target genes. Woerner, S.M., Benner, A., Sutter, C., Schiller, M., Yuan, Y.P., Keller, G., Bork, P., Doeberitz, M.K., Gebert, J.F. Oncogene (2003) [Pubmed]
  44. Comparisons among the Yale-Brown Obsessive-Compulsive Scale, compulsion checklist, and other measures of obsessive-compulsive disorder. Nakagawa, A., Marks, I.M., Takei, N., De Araujo, L.A., Ito, L.M. The British journal of psychiatry : the journal of mental science. (1996) [Pubmed]
  45. The effect of methimazole, iodine and splenocytes on thyroid transplants in BB/Wor rats. Allen, E.M., Bartlett, S.T. Transplantation (1999) [Pubmed]
WikiGenes - Universities