Disease relevance of Napageln

• GP120: Target for Neutralizing HIV-1 Antibodies [1].
• Retraction. Target platelet antigen in homosexual men with immune thrombocytopenia [2].
• mTOR Pathway as a Target in Tissue Hypertrophy [3].
• MEASUREMENTS: Target organ abnormalities were measured by echocardiography and arterial ultrasonography in 61 patients with white coat normotension, 234 with sustained normotension (normal clinic and ambulatory blood pressure), and 64 with sustained hypertension [4].
• Nitric Oxide in Physiologic Concentrations Targets the Translational Machinery to Increase the Proliferation of Human Breast Cancer Cells: Involvement of Mammalian Target of Rapamycin/eIF4E Pathway [5].

Psychiatry related information on Napageln

• Efficacy and side effects were assessed by the Brief Psychiatric Rating Scale, Clinical Global Impressions, Treatment Emergent Symptom Scale, and Target Symptom Ratings [6].
• BACKGROUND: Target symptoms in pharmacotherapy of borderline personality disorder include mood instability, anxiety, and impulsivity [7].
• Outcome was evaluated in a sample of 117 Dutch ambulatory mental health center patients with the SCL-90 Symptom Checklist and the Target Complaints List [8].
• In the "Psychological Refractory Period" (PRP) paradigm, responses are speeded and interference manifests as increased response time for T2 [9].
• Information collected included clinical assessments of Target Lesion Pigmentation, Physician's Global Assessment of Improvement/Worsening, an Assessment of Overall Cosmetic Effect, and a Subject's Self-Assessment Questionnaire [10].

High impact information on Napageln

• 4E-BP activity is controlled by TOR (Target of Rapamycin) [11].
• Murine syngeneic mixed lymphocyte response. I. Target antigens are self Ia molecules [12].
• Suppressor-cell induction in vitro. IV. Target of antigen-specific suppressor factor and its genetic relationships [13].
• Cell-Intrinsic Regulation of Axonal Morphogenesis by the Cdh1-APC Target SnoN [14].
• Mechanism of metabolic control. Target of rapamycin signaling links nitrogen quality to the activity of the Rtg1 and Rtg3 transcription factors [15].

Chemical compound and disease context of Napageln

• Combination Mammalian Target of Rapamycin Inhibitor Rapamycin and HSP90 Inhibitor 17-Allylamino-17-Demethoxygeldanamycin Has Synergistic Activity in Multiple Myeloma [16].
• STATT: a titrate-to-goal study of simvastatin in Asian patients with coronary heart disease. Simvastatin Treats Asians to Target [17].
• Lack of potentiation with felbinac patch on the convulsive toxicity of enoxacin in rats [18].
• National service framework for coronary heart disease. Target of lowering cholesterol by 30% needs to be justified [19].
• Transcriptome Analysis of Temporal Regulation of Carbon Metabolism by CcpA in Bacillus subtilis Reveals Additional Target Genes [20].

Biological context of Napageln

• One DNA fragment that coprecipitated with AGL15 corresponded to a portion of the regulatory region of a gene named DTA1 (for Downstream Target of AGL15-1) [21].
• The Microphthalmia-Associated Transcription Factor Mitf Interacts with {beta}-Catenin To Determine Target Gene Expression [22].
• Inhibition of Mammalian Target of Rapamycin or Apoptotic Pathway Induces Autophagy and Radiosensitizes PTEN Null Prostate Cancer Cells [23].
• Apheresis was started on day 4 in group A and on day 5 in group B. Target CD34(+) cell numbers in apheresis products were >/= 4 x 10(6)/kg recipient BW [24].
• Transgenic analysis shows that this regulation is largely mediated by an evolutionarily conserved sequence within the late element termed PTE (Paired Target Element) [25].

Anatomical context of Napageln

• BACKGROUND: Target lesion calcium is a marker for significant coronary artery disease and a determinant of the success of transcatheter therapy [26].
• HBXIP, Cellular Target of Hepatitis B Virus Oncoprotein, Is a Regulator of Centrosome Dynamics and Cytokinesis [27].
• Targeting the AIB1 Oncogene through Mammalian Target of Rapamycin Inhibition in the Mammary Gland [28].
• A Role for Mammalian Target of Rapamycin in Regulating T Cell Activation versus Anergy [29].
• 3D7-Derived Plasmodium falciparum Erythrocyte Membrane Protein 1 Is a Frequent Target of Naturally Acquired Antibodies Recognizing Protein Domains in a Particular Pattern Independent of Malaria Transmission Intensity [30].

Associations of Napageln with other chemical compounds

• Identification of T-cadherin as a Novel Target of DNA Methyltransferase 3B and Its Role in the Suppression of Nerve Growth Factor-mediated Neurite Outgrowth in PC12 Cells [31].
• Mutational Analysis of Encephalitozoon cuniculi mRNA Cap (Guanine-N7) Methyltransferase, Structure of the Enzyme Bound to Sinefungin, and Evidence That Cap Methyltransferase Is the Target of Sinefungin's Antifungal Activity [32].
• Regulation of Leukocyte Degranulation by cGMP-Dependent Protein Kinase and Phosphoinositide 3-Kinase: Potential Roles in Phosphorylation of Target Membrane SNARE Complex Proteins in Rat Mast Cells [33].
• Dexamethasone Represses Signaling through the Mammalian Target of Rapamycin in Muscle Cells by Enhancing Expression of REDD1 [34].
• Insulin-Mediated Phosphorylation of the Proline-Rich Akt Substrate PRAS40 Is Impaired in Insulin Target Tissues of High-Fat Diet-Fed Rats [35].

Gene context of Napageln

• Human CD4+ T Cells Lyse Target Cells via Granzyme/Perforin upon Circumvention of MHC Class II Restriction by an Antibody-Like Immunoreceptor [36].
• Several of the encoded proteins, including Pep12p/Vps6p (an endosomal target (t) SNARE) and Vps45p (a Sec1p homologue), bind each other directly [1] [37].
• The Insulin-like Growth Factor-binding Protein 1 Gene Is a Primary Target of Peroxisome Proliferator-activated Receptors [38].
• Expression of HIF-1{alpha}, HIF-2{alpha} (EPAS1), and Their Target Genes in Paraganglioma and Pheochromocytoma with VHL and SDH Mutations [39].
• FGFR1 Emerges as a Potential Therapeutic Target for Lobular Breast Carcinomas [40].

Analytical, diagnostic and therapeutic context of Napageln

• Standards for supervised cardiovascular exercise maintenance programs. Report of the Subcommittee on Exercise/Rehabilitation, Target Activity Group [41].
• RESULTS: Early reperfusion was associated with significantly increased odds of achieving a favorable clinical response in patients with a perfusion/diffusion mismatch (odds ratio, 5.4; p = 0.039) and an even more favorable response in patients with the Target Mismatch profile (odds ratio, 8.7; p = 0.011) [42].
• Pathogenesis of DNA repair-deficient cancers: a statistical meta-analysis of putative Real Common Target genes [43].
• Using a structured modelling analysis, the YBOCS and the CC were compared with a latent factor derived from five other variables (Target Rituals, Target Obsession, Clinical Global Impression, Avoidance, Disability) of baseline severity and change after treatment, and also directly with those variables [44].
• CONCLUSION: Target organ-specific interventions that suppress antigen presentation may have an adjunctive role in transplantation tolerance [45].

References