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Gene Review

RpS3A  -  Ribosomal protein S3A

Drosophila melanogaster

Synonyms: 40S ribosomal protein S3a, C3, C3 protein, CG2168, Dmel\CG2168, ...
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High impact information on RpS3A

  • Thus, like other Minute loci, M(4)101 encodes a component of the protein synthesis machinery [1].
  • The C3 gene is located in section 101F of chromosome 4 [2].
  • The most prominent phenotype resulting from antisense depletion of C3 RNA is disappearance of the follicular cells of the ovary (where the concentration of C3 protein is normally high) and abnormalities of the associated germline derivatives, leading to failure of egg production [2].
  • A region of 13 kb harbours the regulatory regions of both ci and pan, transcribed in opposite directions, and a 1.1-kb gene encoding RpS3A [3].

Analytical, diagnostic and therapeutic context of RpS3A


  1. Drosophila RpS3a, a novel Minute gene situated between the segment polarity genescubitus interruptus and dTCF. van Beest, M., Mortin, M., Clevers, H. Nucleic Acids Res. (1998) [Pubmed]
  2. Antisense suppression of the putative ribosomal protein S3A gene disrupts ovarian development in Drosophila melanogaster. Reynaud, E., Bolshakov, V.N., Barajas, V., Kafatos, F.C., Zurita, M. Mol. Gen. Genet. (1997) [Pubmed]
  3. Genetic organization of the ci-M-pan region on chromosome IV in Drosophila melanogaster. Kronhamn, J., Rasmuson-Lestander, A. Genome (1999) [Pubmed]
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