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Gene Review

RpS5a  -  Ribosomal protein S5a

Drosophila melanogaster

Synonyms: 40S ribosomal protein S5a, CG8922, Dmel\CG8922, M(1)15D, M(1)15d, ...
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Disease relevance of RpS5a

  • In the stronger allele (110 bp insert) RPS3 mRNA levels are reduced by approximately 60%, resulting in an extreme Minute phenotype that includes many morphological abnormalities as well as sterility in both males and females due to disruption of early gametogenesis [1].

High impact information on RpS5a

  • This activity is specific to the 99D Minute as it does not suppress other Minute loci elsewhere in the genome [2].
  • This result provides direct evidence that the Minute locus at the 99D interval encodes the ribosomal protein 49 [2].
  • NMR solution structure of a dsRNA binding domain from Drosophila staufen protein reveals homology to the N-terminal domain of ribosomal protein S5 [3].
  • Mutations in ribosomal protein (RP) genes in Drosophila lead to strong developmental phenotypes, expressed in the semi-dominant Minute syndrome [4].
  • The Minute-like defects in the aml1 mutant provide the first evidence that ribosome insufficiency leads to similar consequences in both plants and insects, and emphasize the general importance of efficient protein translation for cell proliferation in higher eukaryotes [4].

Biological context of RpS5a

  • Maternal haploinsufficiency for a third chromosome Minute, M(3)i55, lowers rates of protein synthesis by approximately 30% during the syncytial nuclear cycles of early embryogenesis [5].
  • Moreover, we noticed that this P insertion causes a severe Minute phenotype [6].
  • A Minute encoding a ribosomal protein enhances wing morphogenesis mutants [6].
  • Cell marker mutants located in most of the chromosome arms were used to assess (1) spontaneous and X-ray-induced mitotic recombination frequencies of each Minute, and (2) clone sizes of the different cell marker clones [7].
  • string of pearls encodes Drosophila ribosomal protein S2, has Minute-like characteristics, and is required during oogenesis [8].

Anatomical context of RpS5a

  • Furthermore, embryos from Minute mothers show abnormal expression patterns of the segmentation gene fushi tarazu (ftz) at the cellular blastoderm stage of embryogenesis [5].
  • Our results suggest that the pleiotropic Minute syndrome can affect, probably indirectly, one or more steps of wing morphogenesis that involve surface adhesion of epithelial cells [6].
  • In this report we examine the effects of antisense r-protein 49 expression, a gene known to correspond to a Minute mutation An antisense rp49 gene driven by a strong and inducible promoter was transformed into the Drosophila germ line [9].
  • Pretreatment and posttreatment with calf thymus DNA did not influence the frequency of mutations at the specific loci dp, b, cn and bw as well as Minute mutations induced in Drosophila sperm by X-radiation [10].

Associations of RpS5a with chemical compounds

  • We phenocopied the Minute mutation by injecting wild-type embryos with cycloheximide concentrations which decreased protein synthesis rates to levels comparable with those of Minute embryos [5].

Regulatory relationships of RpS5a


Other interactions of RpS5a


  1. Ribosomal protein insufficiency and the minute syndrome in Drosophila: a dose-response relationship. Saebøe-Larssen, S., Lyamouri, M., Merriam, J., Oksvold, M.P., Lambertsson, A. Genetics (1998) [Pubmed]
  2. A Drosophila Minute gene encodes a ribosomal protein. Kongsuwan, K., Yu, Q., Vincent, A., Frisardi, M.C., Rosbash, M., Lengyel, J.A., Merriam, J. Nature (1985) [Pubmed]
  3. NMR solution structure of a dsRNA binding domain from Drosophila staufen protein reveals homology to the N-terminal domain of ribosomal protein S5. Bycroft, M., Grünert, S., Murzin, A.G., Proctor, M., St Johnston, D. EMBO J. (1995) [Pubmed]
  4. An Arabidopsis Minute-like phenotype caused by a semi-dominant mutation in a RIBOSOMAL PROTEIN S5 gene. Weijers, D., Franke-van Dijk, M., Vencken, R.J., Quint, A., Hooykaas, P., Offringa, R. Development (2001) [Pubmed]
  5. Experimental phenocopy of a minute maternal-effect mutation alters blastoderm determination in embryos of Drosophila melanogaster. Boring, L.F., Sinervo, B., Schubiger, G. Dev. Biol. (1989) [Pubmed]
  6. A Minute encoding a ribosomal protein enhances wing morphogenesis mutants. Hart, K., Klein, T., Wilcox, M. Mech. Dev. (1993) [Pubmed]
  7. Parameters of mitotic recombination in minute mutants of Drosophila melanogaster. Ferrus, A. Genetics (1975) [Pubmed]
  8. string of pearls encodes Drosophila ribosomal protein S2, has Minute-like characteristics, and is required during oogenesis. Cramton, S.E., Laski, F.A. Genetics (1994) [Pubmed]
  9. Generation of Minute phenotypes by a transformed antisense ribosomal protein gene. Patel, R., Jacobs-Lorena, M. Dev. Genet. (1992) [Pubmed]
  10. The influence of calf thymus DNA and deoxyribonucleosides on the induction of different mutation types in drosophila. Ondrej, M. Folia Biol. (Praha) (1975) [Pubmed]
  11. Insertional inactivation of the L13a ribosomal protein gene of Drosophila melanogaster identifies a new Minute locus. Alexander, S.J., Woodling, N.S., Yedvobnick, B. Gene (2006) [Pubmed]
  12. Cloning of the Drosophila melanogaster meiotic recombination gene mei-218: a genetic and molecular analysis of interval 15E. McKim, K.S., Dahmus, J.B., Hawley, R.S. Genetics (1996) [Pubmed]
  13. Drosophila RpS3a, a novel Minute gene situated between the segment polarity genescubitus interruptus and dTCF. van Beest, M., Mortin, M., Clevers, H. Nucleic Acids Res. (1998) [Pubmed]
  14. Genetic analysis of RpL38 and RpL5, two minute genes located in the centric heterochromatin of chromosome 2 of Drosophila melanogaster. Marygold, S.J., Coelho, C.M., Leevers, S.J. Genetics (2005) [Pubmed]
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