High impact information on prc

• Df(3)vin6 embryos, as well as embryos in which prc has been silenced via RNAi, exhibit similar and significant defects in the formation of the heart epithelium [1].
• A prc transgene can partially rescue each of these phenotypes, suggesting that prc regulates these events [1].
• As dorsal closure progresses, Pericardin expression becomes concentrated at the basal surface of the cardioblasts and around the pericardial cells, in close proximity to the dorsal ectoderm [1].
• Pericardin (Prc), a novel Drosophila extracellular matrix protein is a good candidate to participate in heart tube formation [1].

Biological context of prc

• Pericardin, a Drosophila type IV collagen-like protein is involved in the morphogenesis and maintenance of the heart epithelium during dorsal ectoderm closure [1].

References