Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

msn - misshapen

Drosophila melanogaster

Synonyms: 6286, CG16973, DMSN, Dmel\CG16973, HGK, ...

Su, Y.C. et al., Ruan, W. et al., Treisman, J.E. et al., Ruan, W. et al., Paricio, N. et al.

Treisman, Ito, Rubin,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on msn

Here, we show that Bifocal (Bif), a putative cytoskeletal regulator, is a component of the Msn pathway for regulating R cell growth cone targeting. bif displays strong genetic interaction with msn [1].
Loss of msn causes a failure of growth cones to stop at the target, a phenotype similar to loss of dock, whereas overexpression of msn induces pretarget growth cone termination [2].
We show that msn acts in the Frizzled (Fz) mediated epithelial planar polarity (EPP) signaling pathway in eyes and wings [3].
We have performed a structure-function analysis of Msn in vivo in Drosophila in order to elucidate the mechanism whereby Msn regulates JNK and to determine whether msn, like dock, is required for the correct targeting of photoreceptor axons [4].
Mosaic analysis reveals that msn expression is required in photoreceptors in order for their axons to project correctly [4].

Biological context of msn

We propose that msn may act in a signal transduction pathway leading to cytoskeletal re-arrangements [5].
misshapen encodes a protein kinase involved in cell shape control in Drosophila [5].

Anatomical context of msn

The data presented here genetically link msn to two distinct biological events, dorsal closure and photoreceptor axon pathfinding, and thus provide the first evidence that Ste20 kinases of the germinal center kinase family play a role in axonal pathfinding [4].

References

Bifocal is a downstream target of the Ste20-like serine/threonine kinase misshapen in regulating photoreceptor growth cone targeting in Drosophila. Ruan, W., Long, H., Vuong, D.H., Rao, Y. Neuron (2002) [Pubmed]
The SH2/SH3 adaptor protein dock interacts with the Ste20-like kinase misshapen in controlling growth cone motility. Ruan, W., Pang, P., Rao, Y. Neuron (1999) [Pubmed]
The Drosophila STE20-like kinase misshapen is required downstream of the Frizzled receptor in planar polarity signaling. Paricio, N., Feiguin, F., Boutros, M., Eaton, S., Mlodzik, M. EMBO J. (1999) [Pubmed]
The Ste20 kinase misshapen regulates both photoreceptor axon targeting and dorsal closure, acting downstream of distinct signals. Su, Y.C., Maurel-Zaffran, C., Treisman, J.E., Skolnik, E.Y. Mol. Cell. Biol. (2000) [Pubmed]
misshapen encodes a protein kinase involved in cell shape control in Drosophila. Treisman, J.E., Ito, N., Rubin, G.M. Gene (1997) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

TNIK	Bos taurus
tnikb	Danio rerio

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.