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Gene Review

slpr  -  slipper

Drosophila melanogaster

Synonyms: CG2272, D-MLK, Dmel\CG2272, JNKKK, MLK, ...
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High impact information on slpr

  • From these analyses we confirm that failure of dorsal closure is the null phenotype in slpr germline clones [1].
  • In addition, there is a functional maternal contribution, which can suffice for embryogenesis in the zygotic null mutant, but rarely suffices for pupal metamorphosis, revealing later functions for slpr as the maternal contribution is depleted [1].
  • To further define the specific functions of SLPR, we analyzed the phenotypic consequences of slpr loss and gain of function throughout development, using a semiviable maternal-effect allele and wild-type or dominant-negative transgenes [1].
  • Drosophila mixed lineage kinase/slipper, a missing biochemical link in Drosophila JNK signaling [2].
  • Further, dMLK directly phosphorylates Hep, dMKK4 and also their mammalian counterparts, MKK7 and SEK1, in an in vitro kinase assay [2].

Anatomical context of slpr


Associations of slpr with chemical compounds

  • The protein structure analysis of dMLK/slipper revealed, in addition to the conserved domains, a stretch of glutamine in the amino terminus and an asparagine-threonine stretch at the carboxy-terminus [2].


  1. Genetic analysis of slipper/mixed lineage kinase reveals requirements in multiple jun-N-terminal kinase-dependent morphogenetic events during Drosophila development. Polaski, S., Whitney, L., Barker, B.W., Stronach, B. Genetics (2006) [Pubmed]
  2. Drosophila mixed lineage kinase/slipper, a missing biochemical link in Drosophila JNK signaling. Sathyanarayana, P., Barthwal, M.K., Lane, M.E., Acevedo, S.F., Skoulakis, E.M., Bergmann, A., Rana, A. Biochim. Biophys. Acta (2003) [Pubmed]
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