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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

bon  -  bonus

Drosophila melanogaster

Synonyms: 0241/08, 0249/12, 0434/20, 0487/06, 150268_at, ...
 
 
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High impact information on bon

  • The Drosophila bonus (bon) gene encodes a homolog of the vertebrate TIF1 transcriptional cofactors. bon is required for male viability, molting, and numerous events in metamorphosis including leg elongation, bristle development, and pigmentation [1].
  • By immunostaining, we demonstrate that Bonus is associated with both interphase and prophase chromosomes and through chromatin immunoprecipitation show that two of these sites correspond to the histone gene cluster and the Stellate locus [2].

References

  1. Bonus, a Drosophila homolog of TIF1 proteins, interacts with nuclear receptors and can inhibit betaFTZ-F1-dependent transcription. Beckstead, R., Ortiz, J.A., Sanchez, C., Prokopenko, S.N., Chambon, P., Losson, R., Bellen, H.J. Mol. Cell (2001) [Pubmed]
  2. Bonus, a Drosophila TIF1 homolog, is a chromatin-associated protein that acts as a modifier of position-effect variegation. Beckstead, R.B., Ner, S.S., Hales, K.G., Grigliatti, T.A., Baker, B.S., Bellen, H.J. Genetics (2005) [Pubmed]
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