High impact information on PROP1

• Interestingly, missense mutations in the human Prop1 gene causing amino acid changes in both the B1 and B2 regions have been associated with combined pituitary hormone deficiency (CPHD) diseases, suggesting that disruption of nuclear localization may be part of the molecular basis of such diseases [1].
• By comparative analysis of mammalian Prop1 genes and their encoded proteins, including cloning the ovine Prop1 gene and its products, we demonstrate that two conserved basic regions (B1 and B2) of the PROP1 protein located within the homeodomain are required for nuclear localization, DNA binding, and target gene activation [1].
• They were fed lucerne hay cubes and commercial concentrate with and without supplementary calcium propionate (Prop and Cont diets, respectively) in a crossover design for each 21-day period [2].
• With the hyperinsulinemic euglycemic clamp, the glucose infusion rate was lower (P < 0.05) for the Prop diet than the Cont diet, and increased (P < 0.05) after feeding [3].

Associations of PROP1 with chemical compounds

• With the hyperglycemic clamp, the ratio of plasma insulin increment to glucose infusion rate did not differ between the diets, but for the Prop diet the ratio was less during the pre-feeding period [3].
• The rams were fed alfalfa hay without (Cont diet) and with 10 mmol.kg BW-1.d-1 of calcium propionate (Prop diet) for 4 weeks in randomized order [3].

Analytical, diagnostic and therapeutic context of PROP1

• Studies of human patients and animal models with mutations in their Prop1 genes have established that PROP1 is required for the correct development or sustained function of the hormone-secreting cells that regulate physiological pathways controlling growth, reproduction, metabolism, and the stress response [1].

References