Gene Review:
PROP1 - PROP paired-like homeobox 1
Homo sapiens
Synonyms:
CPHD2, Homeobox protein prophet of Pit-1, PROP-1, Pituitary-specific homeodomain factor
- Prop-1 gene expression in human pituitary tumors. Nakamura, S., Ohtsuru, A., Takamura, N., Kitange, G., Tokunaga, Y., Yasunaga, A., Shibata, S., Yamashita, S. J. Clin. Endocrinol. Metab. (1999)
- Role of prophet of Pit1 (PROP1) in gonadotrope differentiation and puberty. Vesper, A.H., Raetzman, L.T., Camper, S.A. Endocrinology (2006)
- Mutation analysis of POUF-1, PROP-1 and HESX-1 show low frequency of mutations in children with sporadic forms of combined pituitary hormone deficiency and septo-optic dysplasia. Rainbow, L.A., Rees, S.A., Shaikh, M.G., Shaw, N.J., Cole, T., Barrett, T.G., Kirk, J.M. Clin. Endocrinol. (Oxf) (2005)
- Transcription factors regulating pituitary development. Parks, J.S., Brown, M.R. Growth Horm. IGF Res. (1999)
- Mutations in PROP1 cause familial combined pituitary hormone deficiency. Wu, W., Cogan, J.D., Pfäffle, R.W., Dasen, J.S., Frisch, H., O'Connell, S.M., Flynn, S.E., Brown, M.R., Mullis, P.E., Parks, J.S., Phillips, J.A., Rosenfeld, M.G. Nat. Genet. (1998)
- Sustained Notch signaling in progenitors is required for sequential emergence of distinct cell lineages during organogenesis. Zhu, X., Zhang, J., Tollkuhn, J., Ohsawa, R., Bresnick, E.H., Guillemot, F., Kageyama, R., Rosenfeld, M.G. Genes Dev. (2006)
- Pituitary hypoplasia and respiratory distress syndrome in Prop1 knockout mice. Nasonkin, I.O., Ward, R.D., Raetzman, L.T., Seasholtz, A.F., Saunders, T.L., Gillespie, P.J., Camper, S.A. Hum. Mol. Genet. (2004)
- Lhx4 and Prop1 are required for cell survival and expansion of the pituitary primordia. Raetzman, L.T., Ward, R., Camper, S.A. Development (2002)
- A unique case of combined pituitary hormone deficiency caused by a PROP1 gene mutation (R120C) associated with normal height and absent puberty. Arroyo, A., Pernasetti, F., Vasilyev, V.V., Amato, P., Yen, S.S., Mellon, P.L. Clin. Endocrinol. (Oxf) (2002)
- Two new PROP1 gene mutations responsible for compound pituitary hormone deficiency. Paracchini, R., Giordano, M., Corrias, A., Mellone, S., Matarazzo, P., Bellone, J., Momigliano-Richiardi, P., Bona, G. Clin. Genet. (2003)
- Cellular determination in the anterior pituitary gland: PIT-1 and PROP-1 mutations as causes of human combined pituitary hormone deficiency. Rodriguez, R., Andersen, B. Minerva Endocrinol. (2003)
- Longitudinal hormonal and pituitary imaging changes in two females with combined pituitary hormone deficiency due to deletion of A301,G302 in the PROP1 gene. Mendonca, B.B., Osorio, M.G., Latronico, A.C., Estefan, V., Lo, L.S., Arnhold, I.J. J. Clin. Endocrinol. Metab. (1999)
- High level expression of Prop-1 gene in gonadotropic cell lines. Aikawa, S., Sato, T., Ono, T., Kato, T., Kato, Y. J. Reprod. Dev. (2006)
- Insufficient adrenarche in patients with combined pituitary hormone deficiency caused by a PROP-1 gene defect. Voutetakis, A., Livadas, S., Sertedaki, A., Maniati-Christidi, M., Dacou-Voutetakis, C. Journal of pediatric endocrinology & metabolism : JPEM. (2001)
- Combined pituitary hormone deficiency: role of Pit-1 and Prop-1. Pfäffle, R.W., Blankenstein, O., Wüller, S., Kentrup, H. Acta paediatrica (Oslo, Norway : 1992). Supplement. (1999)
- A mutational hot spot in the Prop-1 gene in Russian children with combined pituitary hormone deficiency. Fofanova, O.V., Takamura, N., Kinoshita, E., Parks, J.S., Brown, M.R., Peterkova, V.A., Evgrafov, O.V., Goncharov, N.P., Bulatov, A.A., Dedov, I.I., Yamashita, S. Pituitary (1998)
- The molecular basis of human hypogonadotropic hypogonadism. Layman, L.C. Mol. Genet. Metab. (1999)
- "Hot spot" in the PROP1 gene responsible for combined pituitary hormone deficiency. Deladoëy, J., Flück, C., Büyükgebiz, A., Kuhlmann, B.V., Eblé, A., Hindmarsh, P.C., Wu, W., Mullis, P.E. J. Clin. Endocrinol. Metab. (1999)
- Long-term growth hormone therapy in adulthood results in significant linear growth in siblings with a PROP-1 gene mutation. Lee, J.K., Zhu, Y.S., Cordero, J.J., Cai, L.Q., Labour, I., Herrera, C., Imperato-McGinley, J. J. Clin. Endocrinol. Metab. (2004)
- Combined pituitary hormone deficiency in Australian children: clinical and genetic correlates. McLennan, K., Jeske, Y., Cotterill, A., Cowley, D., Penfold, J., Jones, T., Howard, N., Thomsett, M., Choong, C. Clin. Endocrinol. (Oxf) (2003)
- Heritable disorders of pituitary development. Parks, J.S., Brown, M.R., Hurley, D.L., Phelps, C.J., Wajnrajch, M.P. J. Clin. Endocrinol. Metab. (1999)
- Enhanced repression by HESX1 as a cause of hypopituitarism and septooptic dysplasia. Cohen, R.N., Cohen, L.E., Botero, D., Yu, C., Sagar, A., Jurkiewicz, M., Radovick, S. J. Clin. Endocrinol. Metab. (2003)
- A novel PROP1 gene mutation (157delA) in Japanese siblings with combined anterior pituitary hormone deficiency. Tatsumi, K.I., Kikuchi, K., Tsumura, K., Amino, N. Clin. Endocrinol. (Oxf) (2004)
- Functional significance of prop-1 gene expression in pituitary adenomas. Usui, T., Nakamura, Y., Mizuta, H., Murabe, H., Muro, S., Suda, M., Tanaka, K., Tanaka, I., Shimatsu, A., Nakao, K. Endocr. J. (2000)
- The PROP1 2-base pair deletion is a common cause of combined pituitary hormone deficiency. Cogan, J.D., Wu, W., Phillips, J.A., Arnhold, I.J., Agapito, A., Fofanova, O.V., Osorio, M.G., Bircan, I., Moreno, A., Mendonca, B.B. J. Clin. Endocrinol. Metab. (1998)