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Gene Review

ABCA4  -  ATP-binding cassette, sub-family A (ABC1),...

Canis lupus familiaris

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High impact information on ABCA4

  • In order to analyze genetic variation in the coat varieties, we genotyped nine single nucleotide polymorphisms (SNPs) of the ABCA4 gene locus as well as six highly variable microsatellites scattered over the canine genome in the SH and LH populations [1].
  • Four retina-specific genes, ATP binding cassette transporter retina (ABCA4), connexin 36 (CX36), c-mer tyrosin kinase receptor (MERTK) and photoreceptor cell retinol dehydrogenase (RDH12) were investigated in order to identify mutations leading to autosomal recessive (ar) gPRA in 29 breeds of dogs [2].


  1. Long- and short-haired Weimaraner dogs represent two populations of one breed. Schrameyer, T., Dekomien, G., Pasternack, S.M., Reinartz, B.S., Santos, E.J., Epplen, J.T. Electrophoresis (2005) [Pubmed]
  2. Indirect exclusion of four candidate genes for generalized progressive retinal atrophy in several breeds of dogs. Lippmann, T., Pasternack, S.M., Kraczyk, B., Dudek, S.E., Dekomien, G. Journal of negative results in biomedicine (2006) [Pubmed]
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