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Gene Review:

insig1 - insulin induced gene 1

Xenopus laevis

Synonyms: cl-6, cl6

Sadler, S.E. et al., Kwak, J.M. et al., Zhang, Y.H. et al., McLaughlin, J.P. et al., Grigorescu, F. et al.

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High impact information on insig1

Insulin-induced oocyte maturation that was accelerated by 0.01 microM progesterone was also inhibited by low micromolar concentrations of IBMX, demonstrating that the accelerated time course was due to a synergistic potentiation of insulin action by progesterone [1].
Insulin-induced potentiation of the DAMGO response was concentration-dependent and reversed after 1 h [2].
Insulin-induced phosphorylation of ENaC correlates with increased sodium channel function in A6 cells [3].
Insulin induced in oocytes progression through the cell cycle from late G2 to M phase (maturation) [4].

Analytical, diagnostic and therapeutic context of insig1

Insulin-induced maturation of Xenopus oocytes is inhibited by microinjection of a Brassica napus cDNA clone with high similarity to a mammalian receptor for activated protein kinase C [5].

References

A similar pool of cyclic AMP phosphodiesterase in Xenopus oocytes is stimulated by insulin, insulin-like growth factor 1, and [Val12,Thr59]Ha-ras protein. Sadler, S.E., Maller, J.L. J. Biol. Chem. (1989) [Pubmed]
Tyrosine phosphorylation of the mu-opioid receptor regulates agonist intrinsic efficacy. McLaughlin, J.P., Chavkin, C. Mol. Pharmacol. (2001) [Pubmed]
Insulin-induced phosphorylation of ENaC correlates with increased sodium channel function in A6 cells. Zhang, Y.H., Alvarez de la Rosa, D., Canessa, C.M., Hayslett, J.P. Am. J. Physiol., Cell Physiol. (2005) [Pubmed]
Cellular mechanism of metformin action. Grigorescu, F., Laurent, A., Chavanieu, A., Capony, J.P. Diabète & métabolisme. (1991) [Pubmed]
Insulin-induced maturation of Xenopus oocytes is inhibited by microinjection of a Brassica napus cDNA clone with high similarity to a mammalian receptor for activated protein kinase C. Kwak, J.M., Kim, S.A., Lee, S.K., Oh, S.A., Byoun, C.H., Han, J.K., Nam, H.G. Planta (1997) [Pubmed]

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