Chemical Compound Review:
DAMGE (2S)-2-[2-[[(2R)-2-[[(2S)-2- amino-3-(4...
Synonyms:
DAMGO, Dagol, DAGO, RX 783006, Tyr-ala-gly-(nme)phe-gly-ol, ...
- Go mediates the coupling of the mu opioid receptor to adenylyl cyclase in cloned neural cells and brain. Carter, B.D., Medzihradsky, F. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Opioid and adenosine peripheral antinociception are subject to tolerance and withdrawal. Aley, K.O., Green, P.G., Levine, J.D. J. Neurosci. (1995)
- Mu and delta opiate receptors coupled negatively to adenylate cyclase on embryonic neurons from the mouse striatum in primary cultures. Chneiweiss, H., Glowinski, J., Premont, J. J. Neurosci. (1988)
- The absence of a direct correlation between the loss of [D-Ala2, MePhe4,Gly5-ol]Enkephalin inhibition of adenylyl cyclase activity and agonist-induced mu-opioid receptor phosphorylation. El Kouhen, R., Kouhen, O.M., Law, P.Y., Loh, H.H. J. Biol. Chem. (1999)
- Mu-opioid induction of monocyte chemoattractant protein-1, RANTES, and IFN-gamma-inducible protein-10 expression in human peripheral blood mononuclear cells. Wetzel, M.A., Steele, A.D., Eisenstein, T.K., Adler, M.W., Henderson, E.E., Rogers, T.J. J. Immunol. (2000)
- Prolonged effects of repeated social defeat stress on mRNA expression and function of mu-opioid receptors in the ventral tegmental area of rats. Nikulina, E.M., Miczek, K.A., Hammer, R.P. Neuropsychopharmacology (2005)
- Endogenous morphine modulates acute thermonociception in mice. Guarna, M., Bianchi, E., Bartolini, A., Ghelardini, C., Galeotti, N., Bracci, L., Neri, C., Sonetti, D., Stefano, G. J. Neurochem. (2002)
- Kelatorphan, a potent enkephalinases inhibitor, and opioid receptor agonists DAGO and DTLET, differentially modulate self-stimulation behaviour depending on the site of administration. de Witte, P., Heidbreder, C., Roques, B.P. Neuropharmacology (1989)
- Intake of high-fat food is selectively enhanced by mu opioid receptor stimulation within the nucleus accumbens. Zhang, M., Gosnell, B.A., Kelley, A.E. J. Pharmacol. Exp. Ther. (1998)
- mu-Opioid receptor and alpha 2-adrenoceptor agonist binding sites in the postmortem brain of heroin addicts. Gabilondo, A.M., Meana, J.J., Barturen, F., Sastre, M., García-Sevilla, J.A. Psychopharmacology (Berl.) (1994)
- Heterogeneity in presynaptic regulation of GABA release from hippocampal inhibitory neurons. Lambert, N.A., Wilson, W.A. Neuron (1993)
- Sustained potentiation of NMDA receptor-mediated glutamate responses through activation of protein kinase C by a mu opioid. Chen, L., Huang, L.Y. Neuron (1991)
- Opioid receptors from a lower vertebrate (Catostomus commersoni): sequence, pharmacology, coupling to a G-protein-gated inward-rectifying potassium channel (GIRK1), and evolution. Darlison, M.G., Greten, F.R., Harvey, R.J., Kreienkamp, H.J., Stühmer, T., Zwiers, H., Lederis, K., Richter, D. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Purification to homogeneity of an active opioid receptor from rat brain by affinity chromatography. Loukas, S., Mercouris, M., Panetsos, F., Zioudrou, C. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Immunomodulatory activity of mu- and kappa-selective opioid agonists. Taub, D.D., Eisenstein, T.K., Geller, E.B., Adler, M.W., Rogers, T.J. Proc. Natl. Acad. Sci. U.S.A. (1991)
- Kappa- and delta-opioids block sympathetically dependent hyperalgesia. Taiwo, Y.O., Levine, J.D. J. Neurosci. (1991)
- Dissociation of tolerance and dependence for opioid peripheral antinociception in rats. Aley, K.O., Levine, J.D. J. Neurosci. (1997)
- Different mechanisms mediate development and expression of tolerance and dependence for peripheral mu-opioid antinociception in rat. Aley, K.O., Levine, J.D. J. Neurosci. (1997)
- The kappa opioid agonist GR89,696 blocks hyperalgesia and allodynia in rat models of peripheral neuritis and neuropathy. Eliav, E., Herzberg, U., Caudle, R.M. Pain (1999)
- Dopamine and endogenous opioid regulation of picrotoxin-induced locomotion in the ventral pallidum after dopamine depletion in the nucleus accumbens. Churchill, L., Austin, M.C., Kalivas, P.W. Psychopharmacology (Berl.) (1992)
- Locus coeruleus involvement in the learning of classically conditioned bradycardia. Harris, G.C., Fitzgerald, R.D. J. Neurosci. (1991)
- Specific binding of substance P aminoterminal heptapeptide [SP(1-7)] to mouse brain and spinal cord membranes. Igwe, O.J., Kim, D.C., Seybold, V.S., Larson, A.A. J. Neurosci. (1990)
- mu-Opioid receptors modulate NMDA receptor-mediated responses in nucleus accumbens neurons. Martin, G., Nie, Z., Siggins, G.R. J. Neurosci. (1997)
- Inhibitory actions of delta 1-, delta 2-, and mu-opioid receptor agonists on excitatory transmission in lamina II neurons of adult rat spinal cord. Glaum, S.R., Miller, R.J., Hammond, D.L. J. Neurosci. (1994)
- Mu and delta receptors belong to a family of receptors that are coupled to potassium channels. North, R.A., Williams, J.T., Surprenant, A., Christie, M.J. Proc. Natl. Acad. Sci. U.S.A. (1987)
- Dopamine depletion reorganizes projections from the nucleus accumbens and ventral pallidum that mediate opioid-induced motor activity. Churchill, L., Klitenick, M.A., Kalivas, P.W. J. Neurosci. (1998)
- Effects of chronic morphine administration on mu opioid receptor-stimulated [35S]GTPgammaS autoradiography in rat brain. Sim, L.J., Selley, D.E., Dworkin, S.I., Childers, S.R. J. Neurosci. (1996)
- Axotomy reduces the effect of analgesic opioids yet increases the effect of nociceptin on dorsal root ganglion neurons. Abdulla, F.A., Smith, P.A. J. Neurosci. (1998)
- Highly selective photoaffinity labeling of mu and delta opioid receptors. Garbay-Jaureguiberry, C., Robichon, A., Daugé, V., Rossignol, P., Roques, B.P. Proc. Natl. Acad. Sci. U.S.A. (1984)
- Synchronous GABA-mediated potentials and epileptiform discharges in the rat limbic system in vitro. Avoli, M., Barbarosie, M., Lücke, A., Nagao, T., Lopantsev, V., Köhling, R. J. Neurosci. (1996)
- Mu opioid receptor phosphorylation, desensitization, and ligand efficacy. Yu, Y., Zhang, L., Yin, X., Sun, H., Uhl, G.R., Wang, J.B. J. Biol. Chem. (1997)
- mu-Opioid receptor activates signaling pathways implicated in cell survival and translational control. Polakiewicz, R.D., Schieferl, S.M., Gingras, A.C., Sonenberg, N., Comb, M.J. J. Biol. Chem. (1998)
- ADP-ribosylation factor-dependent phospholipase D2 activation is required for agonist-induced mu-opioid receptor endocytosis. Koch, T., Brandenburg, L.O., Schulz, S., Liang, Y., Klein, J., Hollt, V. J. Biol. Chem. (2003)
- STAT5A interacts with and is phosphorylated upon activation of the mu-opioid receptor. Mazarakou, G., Georgoussi, Z. J. Neurochem. (2005)
- A potent and selective endogenous agonist for the mu-opiate receptor. Zadina, J.E., Hackler, L., Ge, L.J., Kastin, A.J. Nature (1997)
- Increased in vivo release of calcitonin gene-related peptide-like material from the spinal cord in arthritic rats. Collin, E., Mantelet, S., Frechilla, D., Pohl, M., Bourgoin, S., Hamon, M., Cesselin, F. Pain (1993)
- G protein-coupled receptor kinase 2 mediates mu-opioid receptor desensitization in GABAergic neurons of the nucleus raphe magnus. Li, A.H., Wang, H.L. J. Neurochem. (2001)