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Gene Review

APOE  -  apolipoprotein E

Pan troglodytes

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Disease relevance of APOE

  • One candidate gene is apolipoprotein E (apoE), with the E3 allele evolved in the genus Homo that reduces the risks for Alzheimer's and vascular disease, as well as influencing inflammation, infection, and neuronal growth [1].

Psychiatry related information on APOE

  • Three common protein isoforms of apolipoprotein E (apoE), encoded by the epsilon2, epsilon3, and epsilon4 alleles of the APOE gene, differ in their association with cardiovascular and Alzheimer's disease risk [2].

High impact information on APOE


  1. Meat-adaptive genes and the evolution of slower aging in humans. Finch, C.E., Stanford, C.B. The Quarterly review of biology. (2004) [Pubmed]
  2. Apolipoprotein E variation at the sequence haplotype level: implications for the origin and maintenance of a major human polymorphism. Fullerton, S.M., Clark, A.G., Weiss, K.M., Nickerson, D.A., Taylor, S.L., Stengârd, J.H., Salomaa, V., Vartiainen, E., Perola, M., Boerwinkle, E., Sing, C.F. Am. J. Hum. Genet. (2000) [Pubmed]
  3. Sequence diversity and large-scale typing of SNPs in the human apolipoprotein E gene. Nickerson, D.A., Taylor, S.L., Fullerton, S.M., Weiss, K.M., Clark, A.G., Stengård, J.H., Salomaa, V., Boerwinkle, E., Sing, C.F. Genome Res. (2000) [Pubmed]
  4. Arginine residues at codons 112 and 158 in the apolipoprotein E gene correspond to the ancestral state in humans. Hanlon, C.S., Rubinsztein, D.C. Atherosclerosis (1995) [Pubmed]
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