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Gene Review

APOE  -  apolipoprotein E

Canis lupus familiaris

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High impact information on APOE

  • Canine smooth muscle cells (SMCs), cultured from amyloid-affected brain blood vessels accumulate Alzheimer amyloid-beta peptide (Abeta) intracellularly, either spontaneously or after treatment with apolipoprotein E (apoE) [1].
  • The present study shows that adipocytes isolated from canine omental fat tissue interact specifically with high density lipoprotein subfractions lacking or enriched in apolipoprotein E, namely canine high density lipoprotein-2 (HDL2) and HDLc, respectively [2].
  • Circular dichroic spectra of apolipoprotein E in model complexes and cholesterol-rich lipoproteins: lipid contribution [3].

Analytical, diagnostic and therapeutic context of APOE


  1. Apolipoprotein E alters metabolism of AbetaPP in cells engaged in beta-amyloidosis. Mazur-Kolecka, B., Frackowiak, J., Krzeslowska, J., Ramakrishna, N., Haske, T., Emmerling, M.R., Zhang, W., Kim, K.S., Wisniewski, H.M. J. Neuropathol. Exp. Neurol. (1999) [Pubmed]
  2. Interactions of high density lipoprotein subclasses (HDL2 and HDLc) with dog adipocytes: selective effects of cholesterol and saturated fat feeding. Fong, B.S., Despres, J.P., Julien, P., Angel, A. J. Lipid Res. (1988) [Pubmed]
  3. Circular dichroic spectra of apolipoprotein E in model complexes and cholesterol-rich lipoproteins: lipid contribution. Chen, G.C., Guo, L.S., Hamilton, R.L., Gordon, V., Richards, E.G., Kane, J.P. Biochemistry (1984) [Pubmed]
  4. Experimental deposition of Alzheimer amyloid beta-protein in canine leptomeningeal vessels. Prior, R., D'Urso, D., Frank, R., Prikulis, I., Pavlakovic, G. Neuroreport (1995) [Pubmed]
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